Advances in Multidimensional Molecular Mechanisms of Epilepsy and Precision Therapy Strategies
- 1Jiangsu Key Laboratory of Tissue Engineering and Neuroregeneration, Co‐Innovation Center of Neuroregeneration Nantong University Nantong Jiangsu People's Republic of China
- 2Department of Emergency Medicine Affiliated Hospital of Nantong University Nantong Jiangsu People's Republic of China
Abstract
Introduction: Epilepsy is a complex neurological disorder characterized by recurrent seizures. A substantial proportion of patients develop drug‐resistant epilepsy (DRE), highlighting the limitations of current therapies and the need to view epilepsy beyond the traditional “channelopathy” hypothesis as a multifactorial network disorder.
Method: This narrative review synthesizes current evidence on epilepsy pathogenesis, mechanisms of drug resistance, and emerging therapeutic strategies. Relevant studies were identified through literature searches of PubMed and Web of Science, with emphasis on publications from 2018 to 2025 and landmark studies that have shaped current understanding of epileptogenesis, drug‐resistant epilepsy, and precision therapy.
Results: The pathogenesis of epilepsy converges genetic, neuroinflammatory, and cellular homeostasis pathways. Key drivers include ion channel mutations, glia‐mediated neuroinflammation, and dysregulated processes like autophagy and ferroptosis. These contribute to drug resistance and comorbidities, driving a therapeutic shift toward precision and network‐modulation strategies, such as gene therapy, targeted pathway modulation, and neuromodulation, with the ultimate goal of achieving disease modification rather than seizure suppression alone.
Conclusions: Integrating multi‐omics insights to construct a holistic precision medicine framework, spanning from molecular diagnosis to tailored network therapy, is fundamental for advancing epilepsy treatment. Future efforts must focus on translating this integrated understanding into effective clinical strategies to overcome therapeutic resistance.
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BibTeX
@article{han2026advances,
title = {{Advances in Multidimensional Molecular Mechanisms of Epilepsy and Precision Therapy Strategies}},
author = {Yimin Han and Jingxuan Xu and Yuntian Shen and Jitai Zhang and Xia Li and Xinlei Yao and Lei Qi and Hualin Sun},
journal = {CNS Neuroscience \& Therapeutics},
year = {2026},
month = nov,
doi = {10.1002/cns.71224},
url = {https://doi.org/10.1002/cns.71224},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Advances in Multidimensional Molecular Mechanisms of Epilepsy and Precision Therapy Strategies
AU - Yimin Han
AU - Jingxuan Xu
AU - Yuntian Shen
AU - Jitai Zhang
AU - Xia Li
AU - Xinlei Yao
AU - Lei Qi
AU - Hualin Sun
PY - 2026
DA - 2026/11/04
JO - CNS Neuroscience & Therapeutics
DO - 10.1002/cns.71224
UR - https://doi.org/10.1002/cns.71224
AB - Introduction: Epilepsy is a complex neurological disorder characterized by recurrent seizures. A substantial proportion of patients develop drug‐resistant epilepsy (DRE), highlighting the limitations of current therapies and the need to view epilepsy beyond the traditional “channelopathy” hypothesis as a multifactorial network disorder. Method: This narrative review synthesizes current evidence on epilepsy pathogenesis, mechanisms of drug resistance, and emerging therapeutic strategies. Relevant studies were identified through literature searches of PubMed and Web of Science, with emphasis on publications from 2018 to 2025 and landmark studies that have shaped current understanding of epileptogenesis, drug‐resistant epilepsy, and precision therapy. Results: The pathogenesis of epilepsy converges genetic, neuroinflammatory, and cellular homeostasis pathways. Key drivers include ion channel mutations, glia‐mediated neuroinflammation, and dysregulated processes like autophagy and ferroptosis. These contribute to drug resistance and comorbidities, driving a therapeutic shift toward precision and network‐modulation strategies, such as gene therapy, targeted pathway modulation, and neuromodulation, with the ultimate goal of achieving disease modification rather than seizure suppression alone. Conclusions: Integrating multi‐omics insights to construct a holistic precision medicine framework, spanning from molecular diagnosis to tailored network therapy, is fundamental for advancing epilepsy treatment. Future efforts must focus on translating this integrated understanding into effective clinical strategies to overcome therapeutic resistance.
SN - 1755-5930
SN - 1755-5949
ER -