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PreprintCC BY-NCChemRxiv

Redirecting Iodine Oxidation in Thyroxine by O-Phosphorylation

  • Marcel Sancken
  • Felix Schindler
  • Boris J. Nachtsheim
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Abstract

[email protected] Abstract O-Phosphorylation of a thyroxine derivative redirects mCPBA oxidation from the internal iodine to a terminal one. A two-step oxidation-hydrolysis sequence delivers the phosphate-stabilised aryl(hydroxy)iodonium salt, whose regiochemistry is established by 3 J-CP-coupling.

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Cite

BibTeXRIS
BibTeX
@misc{sancken2026redirecting,
  title = {{Redirecting Iodine Oxidation in Thyroxine by O-Phosphorylation}},
  author = {Marcel Sancken and Felix Schindler and Boris J. Nachtsheim},
  howpublished = {ChemRxiv},
  year = {2026},
  month = sep,
  doi = {10.26434/chemrxiv.15009163/v1},
  url = {https://chemrxiv.org/doi/full/10.26434/chemrxiv.15009163/v1},
  note = {CC BY-NC},
}
RIS
TY  - UNPB
TI  - Redirecting Iodine Oxidation in Thyroxine by O-Phosphorylation
AU  - Marcel Sancken
AU  - Felix Schindler
AU  - Boris J. Nachtsheim
PY  - 2026
DA  - 2026/09/21
PB  - ChemRxiv
DO  - 10.26434/chemrxiv.15009163/v1
UR  - https://chemrxiv.org/doi/full/10.26434/chemrxiv.15009163/v1
AB  - [email protected] Abstract O-Phosphorylation of a thyroxine derivative redirects mCPBA oxidation from the internal iodine to a terminal one. A two-step oxidation-hydrolysis sequence delivers the phosphate-stabilised aryl(hydroxy)iodonium salt, whose regiochemistry is established by 3 J-CP-coupling.
ER  -