Peer-reviewedCC BY-NC-NDScience
Linking a mutation to survival in wild mice
Abstract
How natural selection affects mouse coat color Evolution, at its core, involves changes in the frequency of alleles subject to natural selection. But identifying the target of selection can be difficult. Barrett et al. investigated how allele frequencies affecting pigmentation change over time (see the Perspective by Pelletier). Wild-caught mice ( Peromyscus maniculatus ) were exposed to avian predators against naturally occurring dark or light backgrounds. Natural selection yielded shifts in coloration owing to genetic variants in the mouse coat color Agouti gene. Science , this issue p. 499 ; see also p. 452
Related
- The VGLUT3-p.T8I Mutation Alters Striatal Acetylcholine Dynamics in Response to Social Stressors and Drives Selective Social Avoidance in Male Mice
- Homozygous kinase-dead Csf1r mutation in outbred mice reveals essential and redundant functions of tissue resident macrophages
- Identification of a novel glutamate receptor 2 mutation in mice presenting progressive cerebellar ataxia
- Does female personality drive mate preference and reproduction in wild house mice?
- Angiotensin receptor blockade does not modify tau pathology in line 66 tau-transgenic mice expressing the P301S mutation
BibTeX
@article{barrett2026linking,
title = {{Linking a mutation to survival in wild mice}},
author = {Rowan D. H. Barrett and Stefan Laurent and Ricardo Mallarino and Susanne P. Pfeifer and Charles C. Y. Xu and Matthieu Foll and Kazumasa Wakamatsu and Jonathan S. Duke-Cohan and Jeffrey D. Jensen and Hopi E. Hoekstra},
journal = {Science},
year = {2026},
month = oct,
doi = {10.1126/science.aav3824},
url = {https://hal.science/hal-05842804v1},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Linking a mutation to survival in wild mice
AU - Rowan D. H. Barrett
AU - Stefan Laurent
AU - Ricardo Mallarino
AU - Susanne P. Pfeifer
AU - Charles C. Y. Xu
AU - Matthieu Foll
AU - Kazumasa Wakamatsu
AU - Jonathan S. Duke-Cohan
AU - Jeffrey D. Jensen
AU - Hopi E. Hoekstra
PY - 2026
DA - 2026/10/28
JO - Science
DO - 10.1126/science.aav3824
UR - https://hal.science/hal-05842804v1
AB - How natural selection affects mouse coat color Evolution, at its core, involves changes in the frequency of alleles subject to natural selection. But identifying the target of selection can be difficult. Barrett et al. investigated how allele frequencies affecting pigmentation change over time (see the Perspective by Pelletier). Wild-caught mice ( Peromyscus maniculatus ) were exposed to avian predators against naturally occurring dark or light backgrounds. Natural selection yielded shifts in coloration owing to genetic variants in the mouse coat color Agouti gene. Science , this issue p. 499 ; see also p. 452
SN - 0036-8075
SN - 1095-9203
ER -