Biophysics
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- SpheroQuaNNt: U-Net–based volume estimation in tumor spheroid and organoid models for assessing preclinical treatment response
- Participant-level Raman spectroscopy of circulating EV-enriched fractions reveals distributed spectral differences in ischemic stroke patients
- Preparation of mouse tumor slices for ex vivo two-photon microscopy
- MechGate: combining mechanism-derived measures of permeation and efflux to screen small molecule drugs targeting Escherichia coli
- Phase Separation of Intracellular Proteins Influences Synaptic Bistability
- Cancers relax selection on charge at the mitochondrial complex I quinone cavity
- Rugnux: from diffraction images to structure at synchrotrons and XFELs in one program
- Correcting Multiple Scattering Enables Dynamical Electron Crystallography in Standard Workflows
- Protein cofactors diversify PRC2 architecture and function
- Replacing H2O with D2O in cryo-EM reduces radiation damage in biological samples
- Single molecule nanopore sensing across a liquid-solid interface
- Agent-guided epitope excision enables economical de novo binder design
- Computational De Novo Design of Miniprotein Candidate Neutralizers Targeting the IL-23 Cytokine Subunit p19
- What Transfers Across Protein Pockets? Experience Reuse in Molecular Optimization for Agentic Structure-Based Drug Design
- Probe Before You Edit: Probing-Guided Molecular Optimization for LLM Agents in Structure-Based Drug Design
- Metabolic-State-Dependent Magnetic Field Effects on Endogenous Flavin Autofluorescence in Escherichia coli
- Choosing a lipid force field for membrane remodeling: pore formation and membrane mimetics in CHARMM36, AMBER Lipid21 and Slipids
- Decoding the Physical Mechanisms of Protein-Small Molecule Association by Multiscale Kinetic Monte-Carlo Simulations
- Rapid femtosecond laser trenching accelerates cryo-electron tomography lamella workflows
- When do bacterial mechanosensitive channels get activated?
- Fluorescence-Based Microviscosity Mapping in Membraneless Organelles
- GAMPoint: Geometry-augmented vision transformer with a multimodal-ready interface for 3D point-cloud segmentation
- Low-affinity exchangeable probes for super-resolution and long-term fluorescence imaging.
- RiboBridge: protein-conditioned de novo RNA binder structure design
- Supercoiling Drives DNA-Protein Co-Condensation