Molecular biology & gene regulation
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- Enhancer binding kinetics explain transcription factor hub formation
- Standardizing Cell Ontology terms for cross-study integration in the female reproductive tract
- Citron kinase activity controls alternative splicing events that drive prostate cancer growth
- Canonical Wnt induction by OTULIN prevents keratinocyte death and skin inflammation
- DNA nanodevice-engineered macrophages as living sensors for dual-mode in vivo monitoring of tumor-associated macrophage polarization
- Atomic structure and dynamics of the mechanosensitive channel MscL from Escherichia coli by cryo-EM and solid-state NMR
- Machine learning–assisted directed evolution of plant Rubisco
- Translocation-induced enhancer rewiring reveals cryptic oncogenic circuits in multiple myeloma
- Rod photoreceptors have a dual dependency on both aerobic glycolysis and OXPHOS and diverge metabolically from other retinal neurons
- Clonal lineage tracing and parallel multiomics profiling reveal transcriptional heterogeneity induced by ARID1A deficiency
- Real-time single-molecule imaging in zebrafish embryos uncovers noncanonical translation
- Genotype-phenotype single-cell transcriptomics for massive parallel assessment of genetic variants
- Freezing-induced solid-liquid microphase separation for self-assembly of functional nucleic acid nanoparticles
- Lipid-organized tetramerization of PLPP1 defines the molecular basis of spatial lipid phosphate signaling
- A cryptic binding pocket regulates the metal-dependent activity of Cas9
- A co-evolved peptide-GPCR system senses host entry to drive fungal infection
- De novo design of miniprotein inhibitors of bacterial adhesins
- Antisense oligonucleotides targeting transcription termination windows disrupt mRNA 3’ end processing and decrease gene expression
- Consecutive waves of NODAL inhibition are required for epiblast patterning
- Single-cell atlas of fetal immunity across lung, spleen, and umbilical cord blood in nonhuman primates
- PI3Kδ is selectively inhibited by roginolisib by stabilizing the C-terminal helix kα12
- ATM promotes nucleolytic processing of reversed replication forks during DNA interstrand cross-link repair
- Combined lactate- and phosphate-dependent cytoplasmic acidification is associated with Mycobacterium tuberculosis growth arrest at acidic pH
- Intercellular GAS6-AXL signaling triggers podocyte cuproptosis in acute kidney injury upstream regulated by CEBPD
- New insights into Müllerian duct differentiation provided by single cell transcriptomics in the chicken embryo