Quantitative Analysis of Boron Trichloride Using ¹¹B Quantitative Nuclear Magnetic Resonance Spectroscopy (qNMR).
- 1Analytical Development Gilead Sciences 1021 Hayter Road Edmonton T6S 1A1 Alberta Canada gilead.com.
Abstract
Boron trichloride (BCl₃) is highly reactive and degrades rapidly when exposed to moisture, complicating analyses, and posing safety risks under standard laboratory conditions. To address these challenges, quantitative ¹¹B nuclear magnetic resonance (qNMR) spectroscopy has been introduced as an analytical method to accurately quantitate boron trichloride in solution. This technique involves the reaction of boron trichloride with methanol to produce trimethyl borate, which is then quantified using an external standard. The preparation process allows for the reaction and sample preparation to occur in a single step within the same vial, ensuring a safe, fast, and reliable analysis. The ¹¹B qNMR method was validated, demonstrating linearity (0.02 M to 0.50 M with r = 0.9999), accuracy (recovery of 100.05%), precision (inter- and intraday), stability, and robustness. This paper highlights the effectiveness of the ¹¹B qNMR method for the accurate, reliable, fast, and safe quantification of boron trichloride in organic solvents such as dichloromethane.
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BibTeX
@article{niekerk2026quantitative,
title = {{Quantitative Analysis of Boron Trichloride Using ¹¹B Quantitative Nuclear Magnetic Resonance Spectroscopy (qNMR).}},
author = {Daniel Van Niekerk and Jaspaul Tatlay and Hilaire V Kemami Wangun and Nicholas J Morehouse},
journal = {Journal of analytical methods in chemistry},
year = {2026},
month = oct,
doi = {10.1155/jamc/4351793},
url = {https://europepmc.org/article/MED/42928886},
note = {CC BY},
}
RIS
TY - JOUR
TI - Quantitative Analysis of Boron Trichloride Using ¹¹B Quantitative Nuclear Magnetic Resonance Spectroscopy (qNMR).
AU - Daniel Van Niekerk
AU - Jaspaul Tatlay
AU - Hilaire V Kemami Wangun
AU - Nicholas J Morehouse
PY - 2026
DA - 2026/10/25
JO - Journal of analytical methods in chemistry
DO - 10.1155/jamc/4351793
UR - https://europepmc.org/article/MED/42928886
AB - Boron trichloride (BCl₃) is highly reactive and degrades rapidly when exposed to moisture, complicating analyses, and posing safety risks under standard laboratory conditions. To address these challenges, quantitative ¹¹B nuclear magnetic resonance (qNMR) spectroscopy has been introduced as an analytical method to accurately quantitate boron trichloride in solution. This technique involves the reaction of boron trichloride with methanol to produce trimethyl borate, which is then quantified using an external standard. The preparation process allows for the reaction and sample preparation to occur in a single step within the same vial, ensuring a safe, fast, and reliable analysis. The ¹¹B qNMR method was validated, demonstrating linearity (0.02 M to 0.50 M with r = 0.9999), accuracy (recovery of 100.05%), precision (inter- and intraday), stability, and robustness. This paper highlights the effectiveness of the ¹¹B qNMR method for the accurate, reliable, fast, and safe quantification of boron trichloride in organic solvents such as dichloromethane.
SN - 2090-8865
SN - 2090-8873
ER -