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Peer-reviewedCC BY-NC-NDTranslational psychiatry

Distributed structural and functional brain alterations associated with irritable bowel syndrome: a coordinate-based multimodal meta-analysis.

  • Valentino Marcel Tahamata1,2,3
  • Tsai-Tsen Liao4,5
  • Yang-Teng Fan6,7
  • Roger Marcelo Martinez1,2,8
  • Yu-Chun Chen9
  • Kah Kheng Goh10,11,12,13
  • Chenyi Chen14,15,16
16 affiliations
  1. 1Graduate Institute of Injury Prevention and Control, College of Public Health, Taipei Medical University, Taipei, Taiwan.
  2. 2Department of Psychiatry, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
  3. 3Psychiatric Research Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
  4. 4Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan.
  5. 5Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei, Taiwan.
  6. 6Graduate Institute of Medicine, Yuan Ze University, Taoyuan, Taiwan.
  7. 7Research Center for Mind, Brain & Learning, National Chengchi University, Taipei, Taiwan.
  8. 8School of Psychological Sciences, National Autonomous University of Honduras, Tegucigalpa, Honduras.
  9. 9Department of Physical Education, National Taiwan University of Sport, Taichung, Taiwan.
  10. 10Graduate Institute of Injury Prevention and Control, College of Public Health, Taipei Medical University, Taipei, Taiwan. [email protected].
  11. 11Department of Psychiatry, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan. [email protected].
  12. 12Psychiatric Research Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan. [email protected].
  13. 13Department of Psychiatry, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. [email protected].
  14. 14Graduate Institute of Injury Prevention and Control, College of Public Health, Taipei Medical University, Taipei, Taiwan. [email protected].
  15. 15Psychiatric Research Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan. [email protected].
  16. 16Research Center for Mind, Brain & Learning, National Chengchi University, Taipei, Taiwan. [email protected].
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Abstract

Irritable bowel syndrome (IBS) is increasingly recognised as being associated with distributed structural and functional brain alterations, yet existing neuroimaging syntheses lack an integrated multimodal approach across imaging paradigms. To address this gap, we systematically meta-analysed IBS-related brain alterations across structural, task-free functional, and task-based functional neuroimaging studies identified through Embase, MEDLINE, PubMed, and Scopus in April 2025. Contrasts comparing IBS with non-IBS controls were synthesised using activation likelihood estimation (ALE), with sensitivity analyses restricted to standard IBS-versus-healthy-control comparisons, and robustness was evaluated through jackknife and within-paper combined-experiment analyses. In the decreased grey matter paradigm, two clusters emerged in the medial thalamus and caudate (8 contrasts, 61 foci, 380 subjects), and largely similar findings were observed in the exploratory combined grey- and white-matter analysis. Task-free analyses identified increased local-metric alterations in the postcentral gyrus (9 contrasts, 51 foci, 528 subjects), increased functional connectivity in insular and paracentral lobule/cingulate regions (15 contrasts, 104 foci, 1 187 subjects), and decreased functional connectivity in the inferior parietal lobule (10 contrasts, 56 foci, 825 subjects). Task-based analyses identified four clusters spanning cortical (insula, medial frontal gyrus) and subcortical (e.g., amygdala, putamen) regions (7 contrasts, 75 foci, 352 subjects). Together, these convergent multimodal findings indicate altered somatosensory, interoceptive, affective, and cognitive processing in IBS, providing a more comprehensive understanding of the distributed structural and functional brain abnormalities associated with the condition.

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Cite

BibTeXRIS
BibTeX
@article{tahamata2026distributed,
  title = {{Distributed structural and functional brain alterations associated with irritable bowel syndrome: a coordinate-based multimodal meta-analysis.}},
  author = {Valentino Marcel Tahamata and Tsai-Tsen Liao and Yang-Teng Fan and Roger Marcelo Martinez and Yu-Chun Chen and Kah Kheng Goh and Chenyi Chen},
  journal = {Translational psychiatry},
  year = {2026},
  month = aug,
  doi = {10.1038/s41398-026-04358-y},
  url = {https://europepmc.org/article/MED/43009475},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Distributed structural and functional brain alterations associated with irritable bowel syndrome: a coordinate-based multimodal meta-analysis.
AU  - Valentino Marcel Tahamata
AU  - Tsai-Tsen Liao
AU  - Yang-Teng Fan
AU  - Roger Marcelo Martinez
AU  - Yu-Chun Chen
AU  - Kah Kheng Goh
AU  - Chenyi Chen
PY  - 2026
DA  - 2026/08/14
JO  - Translational psychiatry
DO  - 10.1038/s41398-026-04358-y
UR  - https://europepmc.org/article/MED/43009475
AB  - Irritable bowel syndrome (IBS) is increasingly recognised as being associated with distributed structural and functional brain alterations, yet existing neuroimaging syntheses lack an integrated multimodal approach across imaging paradigms. To address this gap, we systematically meta-analysed IBS-related brain alterations across structural, task-free functional, and task-based functional neuroimaging studies identified through Embase, MEDLINE, PubMed, and Scopus in April 2025. Contrasts comparing IBS with non-IBS controls were synthesised using activation likelihood estimation (ALE), with sensitivity analyses restricted to standard IBS-versus-healthy-control comparisons, and robustness was evaluated through jackknife and within-paper combined-experiment analyses. In the decreased grey matter paradigm, two clusters emerged in the medial thalamus and caudate (8 contrasts, 61 foci, 380 subjects), and largely similar findings were observed in the exploratory combined grey- and white-matter analysis. Task-free analyses identified increased local-metric alterations in the postcentral gyrus (9 contrasts, 51 foci, 528 subjects), increased functional connectivity in insular and paracentral lobule/cingulate regions (15 contrasts, 104 foci, 1 187 subjects), and decreased functional connectivity in the inferior parietal lobule (10 contrasts, 56 foci, 825 subjects). Task-based analyses identified four clusters spanning cortical (insula, medial frontal gyrus) and subcortical (e.g., amygdala, putamen) regions (7 contrasts, 75 foci, 352 subjects). Together, these convergent multimodal findings indicate altered somatosensory, interoceptive, affective, and cognitive processing in IBS, providing a more comprehensive understanding of the distributed structural and functional brain abnormalities associated with the condition.
SN  - 2158-3188
ER  -