The effect of lifestyle interventions in women with polyendocrine metabolic ovarian syndrome: A systematic review and meta-analysis
10 affiliations
- 1Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, United Kingdom
- 2College of Medicine and Health, University of Birmingham, Birmingham, United Kingdom
- 3Department of Pharmacology, University Medical and Dental College, The University of Faisalabad, Faisalabad, Pakistan
- 4Monash Centre for Health Research and Implementation, Faculty of Clinical and Molecular Medicine, Monash University, Clayton, Victoria, Australia
- 5Diabetes Unit, Monash Health, Clayton, Victoria, Australia
- 6Birmingham Women’s Fertility Centre, Birmingham Women’s and Children’s NHS Foundation Trust, BirminghamUnited Kingdom
- 7Department of OBGYN, Division of Reproductive Endocrinology and Infertility, University of Rochester, Rochester, New York, United States of America
- 8Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, United Kingdom
- 9Liverpool Women’s NHS Foundation Trust, Liverpool, United Kingdom
- 10NIHR Applied Research Collaboration Northwest Coast, Liverpool, United Kingdom
Abstract
Background: Lifestyle interventions are recommended as first-line treatment in polyendocrine metabolic ovarian syndrome (PMOS), but their effectiveness across various outcomes remains unclear. In this systematic review, we evaluate the effectiveness of lifestyle interventions on reproductive, anthropometric, and metabolic outcomes. Methods and findings: We searched Medline, EMBASE, All EBM, PsycInfo, and CINAHL to June 2026 for studies examining lifestyle intervention compared with minimal or no treatment (usual care) in PMOS. Meta-analyses were conducted using random-effects model to estimate pooled odd ratios (OR) with 95% confidence intervals (CI). We conducted subgroup analyses to evaluate differences by intervention type and duration, and by baseline body mass index (BMI). Conclusion: Our review found that lifestyle interventions were associated with improved menstrual regularity and metabolic outcomes in women with PMOS, suggesting complementary benefits as no single intervention showed overall superiority. These findings support international recommendations, which endorse lifestyle interventions as first-line treatment, tailored to individual needs. Why was this study done?: What did the researchers do and find?: What do these findings mean?:
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BibTeX
@article{olalere2026effect,
title = {{The effect of lifestyle interventions in women with polyendocrine metabolic ovarian syndrome: A systematic review and meta-analysis}},
author = {Oladipupo Olalere and Min-Dee Koh and Katie Crabb and Olanike Ajijola and Saba Tariq and Chau Thien Tay and Aya Mousa and Soha Sobhy and Lynne Robinson and Rima Dhillon-Smith and Kathy Hoeger and Lisa Moran and Helena Teede and Shakila Thangaratinam},
journal = {PLOS Medicine},
year = {2026},
month = sep,
doi = {10.1371/journal.pmed.1004887},
url = {https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1004887},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - The effect of lifestyle interventions in women with polyendocrine metabolic ovarian syndrome: A systematic review and meta-analysis
AU - Oladipupo Olalere
AU - Min-Dee Koh
AU - Katie Crabb
AU - Olanike Ajijola
AU - Saba Tariq
AU - Chau Thien Tay
AU - Aya Mousa
AU - Soha Sobhy
AU - Lynne Robinson
AU - Rima Dhillon-Smith
AU - Kathy Hoeger
AU - Lisa Moran
AU - Helena Teede
AU - Shakila Thangaratinam
PY - 2026
DA - 2026/09/23
JO - PLOS Medicine
DO - 10.1371/journal.pmed.1004887
UR - https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1004887
AB - Background: Lifestyle interventions are recommended as first-line treatment in polyendocrine metabolic ovarian syndrome (PMOS), but their effectiveness across various outcomes remains unclear. In this systematic review, we evaluate the effectiveness of lifestyle interventions on reproductive, anthropometric, and metabolic outcomes. Methods and findings: We searched Medline, EMBASE, All EBM, PsycInfo, and CINAHL to June 2026 for studies examining lifestyle intervention compared with minimal or no treatment (usual care) in PMOS. Meta-analyses were conducted using random-effects model to estimate pooled odd ratios (OR) with 95% confidence intervals (CI). We conducted subgroup analyses to evaluate differences by intervention type and duration, and by baseline body mass index (BMI). Conclusion: Our review found that lifestyle interventions were associated with improved menstrual regularity and metabolic outcomes in women with PMOS, suggesting complementary benefits as no single intervention showed overall superiority. These findings support international recommendations, which endorse lifestyle interventions as first-line treatment, tailored to individual needs. Why was this study done?: What did the researchers do and find?: What do these findings mean?:
SN - 1549-1676
ER -