The impact of PGT-A on in vitro fertilization outcomes in advanced-age women: a retrospective cohort study of 1808 Non-PGT-A cycles and 329 PGT-A cycles
- 1Department of Biomedical Engineering, Anhui Medical University
- 2Reproductive Medicine Center, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University
- 3Department of Obstetrics and Gynecology, Core Facility Center, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China
Abstract
Objective To evaluate the effects of preimplantation genetic testing for aneuploidy (PGT-A) on reproductive outcomes in infertile women of advanced maternal age (≥ 35 years). Methods This single-center retrospective cohort study included frozen vitrified-warmed blastocyst transfer (FET) cycles performed from 2019 to 2024. Cycles were divided into a PGT-A group (329 cycles) and a Non-PGT-A group relying solely on morphological embryo screening (1808 cycles). Given the unbalanced sample sizes and baseline characteristics between groups, multivariate logistic regression was used to adjust key confounders and minimize intergroup bias. The primary outcome was live birth rate; secondary outcomes included biochemical pregnancy rate, clinical pregnancy rate, miscarriage rate, cumulative clinical pregnancy rate and cumulative live birth rate. Stratified subgroup analyses were conducted according to maternal age and history of prior spontaneous abortion. Results Compared with the Non-PGT-A group, the PGT-A group demonstrated significantly higher biochemical pregnancy rate (61.70% vs. 43.42%, P < 0.001), clinical pregnancy rate (53.50% vs. 35.56%, P < 0.001), live birth rate (43.47% vs. 25.17%, P < 0.001), cumulative clinical pregnancy rate (66.28% vs. 49.14%, P < 0.001) and cumulative live birth rate (55.94% vs. 37.06%, P < 0.001), alongside a markedly lower miscarriage rate (18.18% vs. 28.77%, P = 0.005). Age-stratified analysis showed significantly higher live birth rates in the PGT-A group among women aged 37–38, 39–40, 41–42 and ≥ 43 years (all P < 0.05). Subgroup stratification by spontaneous abortion history revealed superior live birth rates in the PGT-A arm across all miscarriage subgroups (all P < 0.05). Conclusions For women aged ≥ 37 years, PGT-A is associated with better pregnancy outcomes and live birth rates regardless of prior miscarriage history, supporting its clinical value in optimizing embryo selection for advanced-age patients.
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BibTeX
@article{zhang2026impact,
title = {{The impact of PGT-A on in vitro fertilization outcomes in advanced-age women: a retrospective cohort study of 1808 Non-PGT-A cycles and 329 PGT-A cycles}},
author = {Kuanjian Zhang and Hong Chen and Linlin Song and Cong Jia and Dandan Yang and Zhiguo Zhang},
journal = {European Journal of Medical Research},
year = {2026},
month = aug,
doi = {10.1186/s40001-026-04967-9},
url = {https://doi.org/10.1186/s40001-026-04967-9},
note = {CC BY},
}
RIS
TY - JOUR
TI - The impact of PGT-A on in vitro fertilization outcomes in advanced-age women: a retrospective cohort study of 1808 Non-PGT-A cycles and 329 PGT-A cycles
AU - Kuanjian Zhang
AU - Hong Chen
AU - Linlin Song
AU - Cong Jia
AU - Dandan Yang
AU - Zhiguo Zhang
PY - 2026
DA - 2026/08/01
JO - European Journal of Medical Research
DO - 10.1186/s40001-026-04967-9
UR - https://doi.org/10.1186/s40001-026-04967-9
AB - Objective To evaluate the effects of preimplantation genetic testing for aneuploidy (PGT-A) on reproductive outcomes in infertile women of advanced maternal age (≥ 35 years). Methods This single-center retrospective cohort study included frozen vitrified-warmed blastocyst transfer (FET) cycles performed from 2019 to 2024. Cycles were divided into a PGT-A group (329 cycles) and a Non-PGT-A group relying solely on morphological embryo screening (1808 cycles). Given the unbalanced sample sizes and baseline characteristics between groups, multivariate logistic regression was used to adjust key confounders and minimize intergroup bias. The primary outcome was live birth rate; secondary outcomes included biochemical pregnancy rate, clinical pregnancy rate, miscarriage rate, cumulative clinical pregnancy rate and cumulative live birth rate. Stratified subgroup analyses were conducted according to maternal age and history of prior spontaneous abortion. Results Compared with the Non-PGT-A group, the PGT-A group demonstrated significantly higher biochemical pregnancy rate (61.70% vs. 43.42%, P < 0.001), clinical pregnancy rate (53.50% vs. 35.56%, P < 0.001), live birth rate (43.47% vs. 25.17%, P < 0.001), cumulative clinical pregnancy rate (66.28% vs. 49.14%, P < 0.001) and cumulative live birth rate (55.94% vs. 37.06%, P < 0.001), alongside a markedly lower miscarriage rate (18.18% vs. 28.77%, P = 0.005). Age-stratified analysis showed significantly higher live birth rates in the PGT-A group among women aged 37–38, 39–40, 41–42 and ≥ 43 years (all P < 0.05). Subgroup stratification by spontaneous abortion history revealed superior live birth rates in the PGT-A arm across all miscarriage subgroups (all P < 0.05). Conclusions For women aged ≥ 37 years, PGT-A is associated with better pregnancy outcomes and live birth rates regardless of prior miscarriage history, supporting its clinical value in optimizing embryo selection for advanced-age patients.
SN - 2047-783X
ER -