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Peer-reviewedCC BY-NC-NDIDCases

Cutaneous mucormycosis at the onset of type 1 diabetes in two pediatric patients.

  • Gavin M Thompson1
  • Reenar Yoo1,2
  • Emily J Potts2
  • John C Christenson1,2
  • Katherine M Laycock1,2
  • Zach W Howe2,3
  • Linda A DiMeglio1,4
  • Tamara S Hannon1,4
  • Jonathan Alessi1
  • Manahil Mustafa1,4
  • Amber M Brown1,5
  • Erin R Rudzinski1,6
1 more authors
  • Lindsey M Kirkpatrick1,2
6 affiliations
  1. 1Indiana University School of Medicine, Indianapolis, IN, USA.
  2. 2Riley Hospital for Children - IU Health, Department of Clinical Pediatrics, Division of Pediatric Infectious Diseases, Indianapolis, IN, USA.
  3. 3Riley Hospital for Children - IU Health, Department of Pharmacy, Indianapolis, IN, USA.
  4. 4Riley Hospital for Children - IU Health, Department of Clinical Pediatrics, Division of Pediatric Endocrinology and Diabetology, Indianapolis, IN, USA.
  5. 5Riley Hospital for Children - IU Health, Department of Clinical Pediatrics, Division of Pediatric Critical Care Medicine, Indianapolis, IN, USA.
  6. 6Clinical Pathology and Laboratory Medicine - IU Health, Department of Pathology, Indianapolis, IN, USA.
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Abstract

Type 1 diabetes (T1D) can present with diverse clinical manifestations, including opportunistic infections secondary to hyperglycemia-induced immunosuppression. While bacterial and viral infections (particularly COVID-19) have been well-documented as presenting features of new-onset T1D, mold infections as the initial manifestation remain rare. Mucormycosis, an aggressive angioinvasive fungal infection with high morbidity and mortality, typically occurs in patients who are severely immunocompromised. Here we present two pediatric cases of cutaneous mucormycosis arising at the onset of previously undiagnosed T1D, demonstrating that even newly established hyperglycemia is sufficient to create the conditions necessary for Mucorales invasion at sites of skin injury.

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Cite

BibTeXRIS
BibTeX
@article{thompson2026cutaneous,
  title = {{Cutaneous mucormycosis at the onset of type 1 diabetes in two pediatric patients.}},
  author = {Gavin M Thompson and Reenar Yoo and Emily J Potts and John C Christenson and Katherine M Laycock and Zach W Howe and Linda A DiMeglio and Tamara S Hannon and Jonathan Alessi and Manahil Mustafa and Amber M Brown and Erin R Rudzinski and Lindsey M Kirkpatrick},
  journal = {IDCases},
  year = {2026},
  month = oct,
  doi = {10.1016/j.idcr.2026.e02816},
  url = {https://europepmc.org/article/MED/42999693},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Cutaneous mucormycosis at the onset of type 1 diabetes in two pediatric patients.
AU  - Gavin M Thompson
AU  - Reenar Yoo
AU  - Emily J Potts
AU  - John C Christenson
AU  - Katherine M Laycock
AU  - Zach W Howe
AU  - Linda A DiMeglio
AU  - Tamara S Hannon
AU  - Jonathan Alessi
AU  - Manahil Mustafa
AU  - Amber M Brown
AU  - Erin R Rudzinski
AU  - Lindsey M Kirkpatrick
PY  - 2026
DA  - 2026/10/27
JO  - IDCases
DO  - 10.1016/j.idcr.2026.e02816
UR  - https://europepmc.org/article/MED/42999693
AB  - Type 1 diabetes (T1D) can present with diverse clinical manifestations, including opportunistic infections secondary to hyperglycemia-induced immunosuppression. While bacterial and viral infections (particularly COVID-19) have been well-documented as presenting features of new-onset T1D, mold infections as the initial manifestation remain rare. Mucormycosis, an aggressive angioinvasive fungal infection with high morbidity and mortality, typically occurs in patients who are severely immunocompromised. Here we present two pediatric cases of cutaneous mucormycosis arising at the onset of previously undiagnosed T1D, demonstrating that even newly established hyperglycemia is sufficient to create the conditions necessary for Mucorales invasion at sites of skin injury.
SN  - 2214-2509
ER  -