Ameliorative effect of Gastrodia elata Blume extract on inflammation in a rat model of osteoarthritis.
- 1Department of Biomedical Laboratory Science, Graduate School, Eulji University, Seongnam, Gyeonggi-do, 13156, Republic of Korea.
- 2Department of Biomedical Laboratory Science, Graduate School, Eulji University, Seongnam, Gyeonggi-do, 13156, Republic of Korea. [email protected].
Abstract
Background
Osteoarthritis (OA) is characterized by progressive articular cartilage degeneration, in which inflammatory mediators drive MMP-mediated matrix breakdown and chondrocyte apoptosis, ultimately leading to pain and functional impairment. Although often described as a "wear-and-tear" disease, increasing evidence highlights immune/inflammatory signaling as a key contributor to OA progression. Gastrodia elata Blume (GEB) has reported anti-inflammatory and immunomodulatory activities, but its preventive potential in OA remains unclear. This study evaluated GEB extract in a widely used monosodium iodoacetate (MIA)-induced OA rat model. Male Sprague-Dawley rats (5 weeks old) were assigned to CON, OA, OA + L-GEB, and OA + H-GEB groups; GEB was administered orally once daily for 5 weeks, and OA was induced by intra-articular MIA (3 mg/50 µL) at day 21.Results
GEB improved gross cartilage surface appearance and histopathological outcomes (HE, Safranin O, Alcian blue; Mankin and OARSI scores), showing reduced cartilage damage and better preservation of proteoglycan staining compared with the OA group. Consistently, GEB decreased IL-6, MMP-13, and cleaved caspase-3 in cartilage (IHC) and reduced TUNEL-positive cells, indicating suppression of inflammatory signaling and chondrocyte apoptosis. RT-qPCR further showed downregulation of NF-κB, IL-6, MMP-9, MMP-13, and TIMP-1 mRNA levels in GEB-treated groups versus OA.Conclusions
GEB extract attenuated inflammatory and catabolic responses and inhibited chondrocyte apoptosis in MIA-induced OA, supporting its potential as a prophylactic strategy for localized inflammatory pathology such as osteoarthritis.
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BibTeX
@article{lee2026ameliorative,
title = {{Ameliorative effect of Gastrodia elata Blume extract on inflammation in a rat model of osteoarthritis.}},
author = {Yeon Su Lee and Da Eun Jung and Ji Won Seo and Hyeon Jeong Na and Jeong Su Park and Jin Woo Hong and Hyeon Ju Lee and Jae-Ho Shin},
journal = {Laboratory animal research},
year = {2026},
month = oct,
doi = {10.1186/s42826-026-00297-3},
url = {https://europepmc.org/article/MED/42907941},
note = {CC BY},
}
RIS
TY - JOUR
TI - Ameliorative effect of Gastrodia elata Blume extract on inflammation in a rat model of osteoarthritis.
AU - Yeon Su Lee
AU - Da Eun Jung
AU - Ji Won Seo
AU - Hyeon Jeong Na
AU - Jeong Su Park
AU - Jin Woo Hong
AU - Hyeon Ju Lee
AU - Jae-Ho Shin
PY - 2026
DA - 2026/10/21
JO - Laboratory animal research
DO - 10.1186/s42826-026-00297-3
UR - https://europepmc.org/article/MED/42907941
AB - Background Osteoarthritis (OA) is characterized by progressive articular cartilage degeneration, in which inflammatory mediators drive MMP-mediated matrix breakdown and chondrocyte apoptosis, ultimately leading to pain and functional impairment. Although often described as a "wear-and-tear" disease, increasing evidence highlights immune/inflammatory signaling as a key contributor to OA progression. Gastrodia elata Blume (GEB) has reported anti-inflammatory and immunomodulatory activities, but its preventive potential in OA remains unclear. This study evaluated GEB extract in a widely used monosodium iodoacetate (MIA)-induced OA rat model. Male Sprague-Dawley rats (5 weeks old) were assigned to CON, OA, OA + L-GEB, and OA + H-GEB groups; GEB was administered orally once daily for 5 weeks, and OA was induced by intra-articular MIA (3 mg/50 µL) at day 21.Results GEB improved gross cartilage surface appearance and histopathological outcomes (HE, Safranin O, Alcian blue; Mankin and OARSI scores), showing reduced cartilage damage and better preservation of proteoglycan staining compared with the OA group. Consistently, GEB decreased IL-6, MMP-13, and cleaved caspase-3 in cartilage (IHC) and reduced TUNEL-positive cells, indicating suppression of inflammatory signaling and chondrocyte apoptosis. RT-qPCR further showed downregulation of NF-κB, IL-6, MMP-9, MMP-13, and TIMP-1 mRNA levels in GEB-treated groups versus OA.Conclusions GEB extract attenuated inflammatory and catabolic responses and inhibited chondrocyte apoptosis in MIA-induced OA, supporting its potential as a prophylactic strategy for localized inflammatory pathology such as osteoarthritis.
SN - 1738-6055
SN - 2233-7660
ER -