Significant alteration of gut microbiota in patients with symptomatic uncomplicated diverticular disease
14 affiliations
- 1Department of Gastroenterology, International University of Health and Welfare Ichikawa Hospital
- 2Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine
- 3Department of Gastroenterology, Graduate School of Medicine, International University of Health and Welfare
- 4Biofermin Pharmaceutical Co., Ltd.
- 5Department of Gastroenterology, International University of Health and Welfare Atami Hospital
- 6Department of Gastroenterology, Yokohama Sakae Kyosai Hospital
- 7Department of Internal Medicine, Kanagawa Dental University, Yokohama Clinic
- 8Department of Internal Medicine, Namiki Koiso-Medical Clinic
- 9Department of Biostatistics, JORTC Data Center
- 10Department of Pharmacology, Shimane University Faculty of Medicine
- 11Division of Gastroenterology, Nippon Medical School
- 12Division of Gastroenterology and Hepatology, Department of Medicine, National University Hospital
- 13Yong Loo Lin School of Medicine, National University of Singapore
- 14Territorial Gastroenterology Service, Azienda Sanitaria Locale Barletta-Andria-Trani
Abstract
Mechanisms underlying symptomatic uncomplicated diverticular disease (SUDD) remain unclear. Here, we explored alterations in the gut microbiota associated with SUDD. Patients visiting outpatient clinics for refractory abdominal pain at five Japanese centers between February 2021 and May 2022 were prospectively enrolled. Patients diagnosed with SUDD (n = 29) and those with diverticulosis but not meeting the SUDD criteria (non-SUDD; n = 35) were included. Asymptomatic individuals served as healthy controls (HC; n = 68). Fecal samples were analyzed using 16 S rRNA gene sequencing. α-diversity indices were significantly lower in the SUDD and non-SUDD groups than in the HC group. β-diversity also differed significantly among groups. The abundance of the Ruminococcus gnavus group was higher in the SUDD group than in the non-SUDD and HC groups, whereas that of Coprococcus was lower. Butyrate-producing bacteria were less abundant in the SUDD group. Prediction-based (PICRUSt2) metagenomic analysis suggested upregulation of pathways, such as exopolysaccharide biosynthesis and cell cycle, in the SUDD group. Patients with SUDD exhibited dysbiosis, which may contribute to pathogenesis via impaired epithelial homeostasis, such as decreased mucosal butyrate concentration. The findings of this exploratory, observational study represent associations that require confirmation via direct functional and metabolomic measurements.
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BibTeX
@article{ishibashi2026significant,
title = {{Significant alteration of gut microbiota in patients with symptomatic uncomplicated diverticular disease}},
author = {Fumiaki Ishibashi and Tsumugi Jono and Yuki Kasai and Takaomi Kessoku and Haruka Yokota and Yoshiki Tanaka and Yo Ishihara and Kosuke Tanaka and Kota Takahashi and Kosuke Seita and Takayuki Kato and Eiji Sakai and Takeo Kurihashi and Machiko Nakatogawa and Shunsuke Oyamada and Haruki Usuda and Koichiro Wada and Seiji Futagami and Jonathan Wei Jie Lee and Kok-Ann Gwee and Antonio Tursi and Atsushi Nakajima},
journal = {Scientific Reports},
year = {2026},
month = aug,
doi = {10.1038/s41598-026-67357-5},
url = {https://doi.org/10.1038/s41598-026-67357-5},
note = {CC BY},
}
RIS
TY - JOUR
TI - Significant alteration of gut microbiota in patients with symptomatic uncomplicated diverticular disease
AU - Fumiaki Ishibashi
AU - Tsumugi Jono
AU - Yuki Kasai
AU - Takaomi Kessoku
AU - Haruka Yokota
AU - Yoshiki Tanaka
AU - Yo Ishihara
AU - Kosuke Tanaka
AU - Kota Takahashi
AU - Kosuke Seita
AU - Takayuki Kato
AU - Eiji Sakai
AU - Takeo Kurihashi
AU - Machiko Nakatogawa
AU - Shunsuke Oyamada
AU - Haruki Usuda
AU - Koichiro Wada
AU - Seiji Futagami
AU - Jonathan Wei Jie Lee
AU - Kok-Ann Gwee
AU - Antonio Tursi
AU - Atsushi Nakajima
PY - 2026
DA - 2026/08/01
JO - Scientific Reports
DO - 10.1038/s41598-026-67357-5
UR - https://doi.org/10.1038/s41598-026-67357-5
AB - Mechanisms underlying symptomatic uncomplicated diverticular disease (SUDD) remain unclear. Here, we explored alterations in the gut microbiota associated with SUDD. Patients visiting outpatient clinics for refractory abdominal pain at five Japanese centers between February 2021 and May 2022 were prospectively enrolled. Patients diagnosed with SUDD (n = 29) and those with diverticulosis but not meeting the SUDD criteria (non-SUDD; n = 35) were included. Asymptomatic individuals served as healthy controls (HC; n = 68). Fecal samples were analyzed using 16 S rRNA gene sequencing. α-diversity indices were significantly lower in the SUDD and non-SUDD groups than in the HC group. β-diversity also differed significantly among groups. The abundance of the Ruminococcus gnavus group was higher in the SUDD group than in the non-SUDD and HC groups, whereas that of Coprococcus was lower. Butyrate-producing bacteria were less abundant in the SUDD group. Prediction-based (PICRUSt2) metagenomic analysis suggested upregulation of pathways, such as exopolysaccharide biosynthesis and cell cycle, in the SUDD group. Patients with SUDD exhibited dysbiosis, which may contribute to pathogenesis via impaired epithelial homeostasis, such as decreased mucosal butyrate concentration. The findings of this exploratory, observational study represent associations that require confirmation via direct functional and metabolomic measurements.
SN - 2045-2322
ER -