Lactylation and exercise: A molecular link to disease alleviation (Review).
- 1Department of Physical Education and Safety, Xinjiang Vocational University, Urumqi, Xinjiang Uyghur Autonomous Region 830039, P.R. China.
- 2Department of Rehabilitation, The Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, Jinlin 130117, P.R. China.
Abstract
Regular physical activity improves physical capacity and overall health by enhancing cardiopulmonary function and muscle strength, reducing stress, and improving psychological well‑being and quality of life. Despite these known benefits, the molecular mechanisms that underlie these effects remain incompletely understood. Lactylation, a modification wherein lactate molecules form ester bonds with proteins, induces functional changes in these proteins. Evidence indicates that exercise can regulate lactylation, which, in turn, affects intracellular signaling pathways and metabolic processes. This modulation plays a role in promoting health and facilitating disease alleviation. The present review offers an extensive review of the mechanisms through which exercise influences lactylation and discusses the potential clinical applications of lactylation in the prevention and treatment of exercise‑related diseases.
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BibTeX
@article{wang2026lactylation,
title = {{Lactylation and exercise: A molecular link to disease alleviation (Review).}},
author = {Jian Wang and Lei Wu},
journal = {Molecular medicine reports},
year = {2026},
month = oct,
doi = {10.3892/mmr.2026.14035},
url = {https://europepmc.org/article/MED/42852621},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Lactylation and exercise: A molecular link to disease alleviation (Review).
AU - Jian Wang
AU - Lei Wu
PY - 2026
DA - 2026/10/09
JO - Molecular medicine reports
DO - 10.3892/mmr.2026.14035
UR - https://europepmc.org/article/MED/42852621
AB - Regular physical activity improves physical capacity and overall health by enhancing cardiopulmonary function and muscle strength, reducing stress, and improving psychological well‑being and quality of life. Despite these known benefits, the molecular mechanisms that underlie these effects remain incompletely understood. Lactylation, a modification wherein lactate molecules form ester bonds with proteins, induces functional changes in these proteins. Evidence indicates that exercise can regulate lactylation, which, in turn, affects intracellular signaling pathways and metabolic processes. This modulation plays a role in promoting health and facilitating disease alleviation. The present review offers an extensive review of the mechanisms through which exercise influences lactylation and discusses the potential clinical applications of lactylation in the prevention and treatment of exercise‑related diseases.
SN - 1791-2997
SN - 1791-3004
ER -