The Effect of Packed Red Blood Cell Transfusion on Complete Blood Count and Hemoglobin Fractions in Adult Patients with Sickle Cell Disease: A Prospective Single-Center Cohort Study in Saudi Arabia.
6 affiliations
- 1Adult Hematology Unit, Internal Medicine Department, King Fahd Military Medical Complex, Dhahran 31932, Saudi Arabia.
- 2College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam 34212, Saudi Arabia.
- 3Laboratory Department, King Fahd Military Medical Complex, Dhahran 31932, Saudi Arabia.
- 4Internal medicine Department, King Fahd Military Medical Complex, Dhahran 31932, Saudi Arabia.
- 5Vice Deanship of Postgraduate Studies and Scientific Research, Prince Sultan Military Collage of Health Sciences, Dhahran 31932, Saudi Arabia.
- 6Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK.
Abstract
Background: Sickle cell disease (SCD) is a genetic disease where a mutation in beta-globin results in an increased hemoglobin S percentage (Hgb S%), which is responsible for the crisis. The aim of this study was to determine the impact of each unit packed red blood cell (PRBC) simple transfusion on complete blood count (CBC) and high-performance liquid chromatography (HPLC) parameters in adult patients with SCD. Methods: This prospective cohort study was conducted between 29 September 2024, and 30 July 2025, among n = 65 SCD patients requiring hospitalization in the hematology department for blood transfusions. Medication, frequency of admission, and demographic information were obtained from the health informatics system. In addition, CBC, white blood cell (WBC), hemoglobin (Hgb), platelet (Plt), and HPLC data were obtained within 24 h before and after the PRBC transfusion. Results: Of n = 65 SCD patients, 87.7% matched the SS phenotype; 58.5% were females; the mean age was 27.23 years. Blood group O+ accounted for 50.8% of the patients, followed by A+ (33.8%). The mean Hgb values before and after transfusion were 7.16 (standard deviation (SD) 0.82) and 8.67 (SD 0.96), respectively (p < 0.001). The mean Hgb S% values before and after transfusion were 71.25 (SD12.19) and 55.97 (SD11.24), respectively (p < 0.001). The difference in the mean values of WBC, Hgb F% and Hgb A% (p < 0.001), as well as Hgb A2% (p = 0.006), changed significantly before and after blood transfusion. A negative correlation between body mass index (BMI) and changes in Plt count was found (p = 0.009). Conclusions: This study quantified the impact of each PRBC unit on CBC and HPLC parameters. While these findings may support strategies to reduce alloimmunization, this outcome was not evaluated and requires further study.
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BibTeX
@article{alansari2026effect,
title = {{The Effect of Packed Red Blood Cell Transfusion on Complete Blood Count and Hemoglobin Fractions in Adult Patients with Sickle Cell Disease: A Prospective Single-Center Cohort Study in Saudi Arabia.}},
author = {Rehab Yusuf Al-Ansari and Fatimah Salem Al Ayidh and Rayan Mansour Aljurbua and Mohammed Ibrahim AlJamily and Yassr Abdullah Alsubaie and Abdulelah Abdulrahman Almugahwi and Tawasoul Fadoul and Abdulrahman Hassan Halawi and Zechariah Jebakumar Arulanantham and Alexander Woodman},
journal = {Medical sciences (Basel, Switzerland)},
year = {2026},
month = oct,
doi = {10.3390/medsci14060668},
url = {https://europepmc.org/article/MED/42930586},
note = {CC BY},
}
RIS
TY - JOUR
TI - The Effect of Packed Red Blood Cell Transfusion on Complete Blood Count and Hemoglobin Fractions in Adult Patients with Sickle Cell Disease: A Prospective Single-Center Cohort Study in Saudi Arabia.
AU - Rehab Yusuf Al-Ansari
AU - Fatimah Salem Al Ayidh
AU - Rayan Mansour Aljurbua
AU - Mohammed Ibrahim AlJamily
AU - Yassr Abdullah Alsubaie
AU - Abdulelah Abdulrahman Almugahwi
AU - Tawasoul Fadoul
AU - Abdulrahman Hassan Halawi
AU - Zechariah Jebakumar Arulanantham
AU - Alexander Woodman
PY - 2026
DA - 2026/10/13
JO - Medical sciences (Basel, Switzerland)
DO - 10.3390/medsci14060668
UR - https://europepmc.org/article/MED/42930586
AB - Background: Sickle cell disease (SCD) is a genetic disease where a mutation in beta-globin results in an increased hemoglobin S percentage (Hgb S%), which is responsible for the crisis. The aim of this study was to determine the impact of each unit packed red blood cell (PRBC) simple transfusion on complete blood count (CBC) and high-performance liquid chromatography (HPLC) parameters in adult patients with SCD. Methods: This prospective cohort study was conducted between 29 September 2024, and 30 July 2025, among n = 65 SCD patients requiring hospitalization in the hematology department for blood transfusions. Medication, frequency of admission, and demographic information were obtained from the health informatics system. In addition, CBC, white blood cell (WBC), hemoglobin (Hgb), platelet (Plt), and HPLC data were obtained within 24 h before and after the PRBC transfusion. Results: Of n = 65 SCD patients, 87.7% matched the SS phenotype; 58.5% were females; the mean age was 27.23 years. Blood group O+ accounted for 50.8% of the patients, followed by A+ (33.8%). The mean Hgb values before and after transfusion were 7.16 (standard deviation (SD) 0.82) and 8.67 (SD 0.96), respectively (p < 0.001). The mean Hgb S% values before and after transfusion were 71.25 (SD12.19) and 55.97 (SD11.24), respectively (p < 0.001). The difference in the mean values of WBC, Hgb F% and Hgb A% (p < 0.001), as well as Hgb A2% (p = 0.006), changed significantly before and after blood transfusion. A negative correlation between body mass index (BMI) and changes in Plt count was found (p = 0.009). Conclusions: This study quantified the impact of each PRBC unit on CBC and HPLC parameters. While these findings may support strategies to reduce alloimmunization, this outcome was not evaluated and requires further study.
SN - 2076-3271
ER -