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Peer-reviewedCC BYThe journal of physiological sciences : JPS

VEGFR-dependent signaling contributes to postnatal brown adipose tissue development in Syrian hamsters.

  • Khaled Mahmud Sujan1
  • Yukino Tamakoshi2
  • Bong Soo Seok2
  • Zibo Yang2
  • Shucheng Xu2
  • Mohamed Elfeky3
  • Mira Kato-Suzuki2
  • Yuko Okamatsu-Ogura4
4 affiliations
  1. 1Laboratory of Biochemistry, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, 060-0818, Japan; Department of Physiology, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh, 2202, Bangladesh.
  2. 2Laboratory of Biochemistry, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, 060-0818, Japan.
  3. 3Laboratory of Biochemistry, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, 060-0818, Japan; Department of Biochemistry, Faculty of Veterinary Medicine, Alexandria University, Alexandria, 21526, Egypt.
  4. 4Laboratory of Biochemistry, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, 060-0818, Japan. Electronic address: [email protected].
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Abstract

In most mammals, brown adipose tissue (BAT) forms before or soon after birth, whereas Syrian hamsters are born without BAT, which develops postnatally through the proliferation and differentiation of brown adipocyte progenitors. Since sympathetic innervation and vascularization are critical for BAT function, we examined their roles in postnatal BAT formation using interscapular adipose tissue from postnatal day (P) 6-14 hamsters. Putative progenitor-like cells were sparsely distributed at P6 and became progressively more abundant throughout the tissue with postnatal age. Sympathetic innervation emerged after P8, whereas blood vessels were detectable from P6 and increased with age during BAT development. Inhibition of vascular endothelial growth factor receptor (VEGFR) signaling by SU5416 significantly reduced cell proliferation and UCP1 expression. These findings suggest that VEGFR-dependent signaling contributes to postnatal BAT development in Syrian hamsters.

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Cite

BibTeXRIS
BibTeX
@article{sujan2026vegfrdependent,
  title = {{VEGFR-dependent signaling contributes to postnatal brown adipose tissue development in Syrian hamsters.}},
  author = {Khaled Mahmud Sujan and Yukino Tamakoshi and Bong Soo Seok and Zibo Yang and Shucheng Xu and Mohamed Elfeky and Mira Kato-Suzuki and Yuko Okamatsu-Ogura},
  journal = {The journal of physiological sciences : JPS},
  year = {2026},
  month = oct,
  doi = {10.1016/j.jphyss.2026.100106},
  url = {https://europepmc.org/article/MED/42874135},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - VEGFR-dependent signaling contributes to postnatal brown adipose tissue development in Syrian hamsters.
AU  - Khaled Mahmud Sujan
AU  - Yukino Tamakoshi
AU  - Bong Soo Seok
AU  - Zibo Yang
AU  - Shucheng Xu
AU  - Mohamed Elfeky
AU  - Mira Kato-Suzuki
AU  - Yuko Okamatsu-Ogura
PY  - 2026
DA  - 2026/10/07
JO  - The journal of physiological sciences : JPS
DO  - 10.1016/j.jphyss.2026.100106
UR  - https://europepmc.org/article/MED/42874135
AB  - In most mammals, brown adipose tissue (BAT) forms before or soon after birth, whereas Syrian hamsters are born without BAT, which develops postnatally through the proliferation and differentiation of brown adipocyte progenitors. Since sympathetic innervation and vascularization are critical for BAT function, we examined their roles in postnatal BAT formation using interscapular adipose tissue from postnatal day (P) 6-14 hamsters. Putative progenitor-like cells were sparsely distributed at P6 and became progressively more abundant throughout the tissue with postnatal age. Sympathetic innervation emerged after P8, whereas blood vessels were detectable from P6 and increased with age during BAT development. Inhibition of vascular endothelial growth factor receptor (VEGFR) signaling by SU5416 significantly reduced cell proliferation and UCP1 expression. These findings suggest that VEGFR-dependent signaling contributes to postnatal BAT development in Syrian hamsters.
SN  - 1880-6546
SN  - 1880-6562
ER  -