Sleep duration and risk of post-stroke depression: a systematic review and meta-analysis
- 1School of Nursing, Beihua University
- 2Department of Gastroenterology, Jilin City People’s Hospital
Abstract
Background: Post-stroke depression frequently occurs as a complication following a stroke, with sleep duration identified as a risk factor. However, the relationship between sleep duration and the risk of post-stroke depression remains controversial.
Objective: To investigate the association between sleep duration and the risk of post-stroke depression.
Methods: Relevant studies investigating the association between sleep duration and post-stroke depression were searched in five English databases (PubMed, Cochrane Library, Embase, Web of Science, and CINAHL) and four Chinese databases (CNKI, Wanfang Data, VIP Database, and China Biology Medicine Database) from inception to January 2026. Data extraction and quality assessment of the included literature were independently performed by two investigators. Meta-analyses were conducted using Stata 16.0 software. Pooled odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were calculated using either a fixed-effects or a random-effects model.
Results: The analysis included 6 articles, encompassing a total of 5,624 cases. Meta-analysis showed that short sleep duration was associated with an increased risk of post-stroke depression [OR = 1.93, 95% CI(1.56–2.38), p < 0.05], whereas long sleep duration was not significantly associated with the risk [OR = 1.29, 95% CI(1.00–1.66), p > 0.05].
Conclusion: Sleep duration is associated with the risk of post-stroke depression, with shorter sleep duration elevating this risk. Future studies should be incorporated to enhance the reliability of these findings.
Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD42024609869 , identifier CRD42024609869.
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BibTeX
@article{li2026sleep,
title = {{Sleep duration and risk of post-stroke depression: a systematic review and meta-analysis}},
author = {Mengyuan Li and Huihui Zhu and Furong Sui and Yican Tian and Wenyu Tang and Jingui Lai and Lu Wang and Lin Zhang and Yan Song},
journal = {Frontiers in Neurology},
year = {2026},
month = oct,
doi = {10.3389/fneur.2026.1914895},
url = {https://www.frontiersin.org/articles/10.3389/fneur.2026.1914895/full},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Sleep duration and risk of post-stroke depression: a systematic review and meta-analysis
AU - Mengyuan Li
AU - Huihui Zhu
AU - Furong Sui
AU - Yican Tian
AU - Wenyu Tang
AU - Jingui Lai
AU - Lu Wang
AU - Lin Zhang
AU - Yan Song
PY - 2026
DA - 2026/10/29
JO - Frontiers in Neurology
DO - 10.3389/fneur.2026.1914895
UR - https://www.frontiersin.org/articles/10.3389/fneur.2026.1914895/full
AB - Background: Post-stroke depression frequently occurs as a complication following a stroke, with sleep duration identified as a risk factor. However, the relationship between sleep duration and the risk of post-stroke depression remains controversial. Objective: To investigate the association between sleep duration and the risk of post-stroke depression. Methods: Relevant studies investigating the association between sleep duration and post-stroke depression were searched in five English databases (PubMed, Cochrane Library, Embase, Web of Science, and CINAHL) and four Chinese databases (CNKI, Wanfang Data, VIP Database, and China Biology Medicine Database) from inception to January 2026. Data extraction and quality assessment of the included literature were independently performed by two investigators. Meta-analyses were conducted using Stata 16.0 software. Pooled odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were calculated using either a fixed-effects or a random-effects model. Results: The analysis included 6 articles, encompassing a total of 5,624 cases. Meta-analysis showed that short sleep duration was associated with an increased risk of post-stroke depression [OR = 1.93, 95% CI(1.56–2.38), p < 0.05], whereas long sleep duration was not significantly associated with the risk [OR = 1.29, 95% CI(1.00–1.66), p > 0.05]. Conclusion: Sleep duration is associated with the risk of post-stroke depression, with shorter sleep duration elevating this risk. Future studies should be incorporated to enhance the reliability of these findings. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD42024609869 , identifier CRD42024609869.
SN - 1664-2295
ER -