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Peer-reviewedCC BY-NC-ND 4.0The Australasian Journal of Dermatology

Dupilumab‐Associated Erythema Multiforme‐Like Eruption With Lichenoid Histology in a Paediatric Patient: A Case Report

  • Paul Sun Woo Kim1,2
  • Jacqueline Tu1,2
  • Kelvin Truong1,2
  • Gloria Fong1,2
  • William Luu1,2
  • Narinder Kaur3
  • Miriam Fewtrell4
  • Li‐Chuen Wong1,2
4 affiliations
  1. 1Sydney Medical School, Faculty of Medicine and Health The University of Sydney Sydney New South Wales Australia
  2. 2Department of Dermatology The Children's Hospital at Westmead Sydney New South Wales Australia
  3. 3Hills Allergy and Specialists Clinic Sydney New South Wales Australia
  4. 4Department of Histopathology The Children's Hospital at Westmead Sydney New South Wales Australia
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Abstract

Dupilumab‐associated erythema multiforme and lichenoid eruptions have been previously reported as rare dermatological adverse events. We present an atypical paediatric case of a dupilumab‐associated erythema multiforme‐like eruption in a 5‐year‐old male eczema patient, who developed erythematous targetoid papules and plaques over the upper and lower limbs, with a biopsy suggestive of a lichenoid interface reaction. Dupilumab was discontinued, and the side effect was managed with topical corticosteroids, leading to resolution of the lesions with mild residual post‐inflammatory skin hyperpigmentation.

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Cite

BibTeXRIS
BibTeX
@article{kim2026dupilumabassociated,
  title = {{Dupilumab‐Associated Erythema Multiforme‐Like Eruption With Lichenoid Histology in a Paediatric Patient: A Case Report}},
  author = {Paul Sun Woo Kim and Jacqueline Tu and Kelvin Truong and Gloria Fong and William Luu and Narinder Kaur and Miriam Fewtrell and Li‐Chuen Wong},
  journal = {The Australasian Journal of Dermatology},
  year = {2026},
  month = jul,
  doi = {10.1111/ajd.70175},
  url = {https://doi.org/10.1111/ajd.70175},
  note = {CC BY-NC-ND 4.0},
}
RIS
TY  - JOUR
TI  - Dupilumab‐Associated Erythema Multiforme‐Like Eruption With Lichenoid Histology in a Paediatric Patient: A Case Report
AU  - Paul Sun Woo Kim
AU  - Jacqueline Tu
AU  - Kelvin Truong
AU  - Gloria Fong
AU  - William Luu
AU  - Narinder Kaur
AU  - Miriam Fewtrell
AU  - Li‐Chuen Wong
PY  - 2026
DA  - 2026/07/07
JO  - The Australasian Journal of Dermatology
DO  - 10.1111/ajd.70175
UR  - https://doi.org/10.1111/ajd.70175
AB  - Dupilumab‐associated erythema multiforme and lichenoid eruptions have been previously reported as rare dermatological adverse events. We present an atypical paediatric case of a dupilumab‐associated erythema multiforme‐like eruption in a 5‐year‐old male eczema patient, who developed erythematous targetoid papules and plaques over the upper and lower limbs, with a biopsy suggestive of a lichenoid interface reaction. Dupilumab was discontinued, and the side effect was managed with topical corticosteroids, leading to resolution of the lesions with mild residual post‐inflammatory skin hyperpigmentation.
SN  - 0004-8380
SN  - 1440-0960
ER  -