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Peer-reviewedCC BY-NC-NDInternational wound journal

Multidimensional Wound Healing Outcomes in Chronic and Complex Wounds: A Real-World Case Series With a Thermoreversible Wound Gel.

  • Iris Noland1
  • Miloslav Sailer2
  • Jeyachchandran Visvalingam2
  • Rohan Pointer2
  • Robert B Huizinga2
  1. 1Colborne Clinic, Colborne, Ontario, Canada.
  2. 2Kane Biotech, Winnipeg, Manitoba, Canada.
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Abstract

Chronic and complex wounds frequently exhibit delayed healing associated with persistent inflammation, microbial burden and biofilm formation. This prospective observational case series describes wound-healing outcomes associated with adjunctive use of a thermo-reversible antimicrobial wound gel (TRG) in 17 adult patients with chronic wounds treated in an outpatient setting. A total of 28 wounds were analysed over up to 12 weeks using clinically relevant endpoints including percentage area reduction (PAR), wound bed tissue composition, exudate level, tissue oxygenation and patient-reported pain. Mean PAR was 43.9% at the wound level and 42.7% at the patient level. The proportion of wounds demonstrating epithelial tissue increased from 25.0% to 68.8%, while necrotic tissue decreased from 25.0% to 12.5%. Low exudate increased from 41.2% at baseline to 64.7% at final assessment. Mean pain scores decreased from 4.76 to 2.18 (p = 0.0125). In patients with available tissue oxygenation data, change in oxygenation was positively correlated with PAR (p = 0.011). These findings suggest that adjunctive use of the TRG was associated with improvement across multiple clinical outcomes in a real-world population of patients with chronic and complex wounds and support further evaluation in controlled studies.

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Cite

BibTeXRIS
BibTeX
@article{noland2026multidimensional,
  title = {{Multidimensional Wound Healing Outcomes in Chronic and Complex Wounds: A Real-World Case Series With a Thermoreversible Wound Gel.}},
  author = {Iris Noland and Miloslav Sailer and Jeyachchandran Visvalingam and Rohan Pointer and Robert B Huizinga},
  journal = {International wound journal},
  year = {2026},
  month = oct,
  doi = {10.1111/iwj.71081},
  url = {https://europepmc.org/article/MED/42958607},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Multidimensional Wound Healing Outcomes in Chronic and Complex Wounds: A Real-World Case Series With a Thermoreversible Wound Gel.
AU  - Iris Noland
AU  - Miloslav Sailer
AU  - Jeyachchandran Visvalingam
AU  - Rohan Pointer
AU  - Robert B Huizinga
PY  - 2026
DA  - 2026/10/29
JO  - International wound journal
DO  - 10.1111/iwj.71081
UR  - https://europepmc.org/article/MED/42958607
AB  - Chronic and complex wounds frequently exhibit delayed healing associated with persistent inflammation, microbial burden and biofilm formation. This prospective observational case series describes wound-healing outcomes associated with adjunctive use of a thermo-reversible antimicrobial wound gel (TRG) in 17 adult patients with chronic wounds treated in an outpatient setting. A total of 28 wounds were analysed over up to 12 weeks using clinically relevant endpoints including percentage area reduction (PAR), wound bed tissue composition, exudate level, tissue oxygenation and patient-reported pain. Mean PAR was 43.9% at the wound level and 42.7% at the patient level. The proportion of wounds demonstrating epithelial tissue increased from 25.0% to 68.8%, while necrotic tissue decreased from 25.0% to 12.5%. Low exudate increased from 41.2% at baseline to 64.7% at final assessment. Mean pain scores decreased from 4.76 to 2.18 (p = 0.0125). In patients with available tissue oxygenation data, change in oxygenation was positively correlated with PAR (p = 0.011). These findings suggest that adjunctive use of the TRG was associated with improvement across multiple clinical outcomes in a real-world population of patients with chronic and complex wounds and support further evaluation in controlled studies.
SN  - 1742-4801
SN  - 1742-481X
ER  -