Skip to content
DraconiticResearch
Search Sources API
203,234 studies31 sourcesUpdated 22 min ago
Peer-reviewedCC BY 4.0PLOS Biology

Conserved spike epitopes persist in generalist bat sarbecoviruses

  • Matthew B. Frieman1
  1. 1Center for Pathogen Research, The Department of Microbiology and Immunology, The University of Maryland School of Medicine, Baltimore, Maryland, United States of America
Read full textPDFDOICite

Abstract

Bat sarbecoviruses differ in the range of mammalian ACE2 receptors they can use, complicating predictions of spillover risk. Two new studies in PLOS Biology link receptor breadth with antigenic relatedness and reveal conserved spike epitopes targetable by antibodies.

Bat sarbecoviruses differ in the range of mammalian ACE2 receptors they can use, complicating predictions of spillover risk. This Primer comments on two new studies in PLOS Biology that link receptor breadth with antigenic relatedness and reveal conserved spike epitopes targetable by antibodies.

Related

  1. Structural basis of diverse antibody recognition of conserved coronavirus spike S2 epitopes that contribute to protective immunity
    A. A. Rubio, V. Crivelli, V. Hönig +22
    bioRxivPreprintCC BYFull textBiophysicsbioRxiv
  2. In silico characterization of ferritin 2 conserved motifs and B-cell epitopes in Hyalomma anatolicum.
    Xueqing Zhao, Zeyun Cui, Na Zhou +5
    Journal of veterinary sciencePeer-reviewedCC BYFull textMolecular biology & gene regulationEurope PMC
  3. Unexpected Localization of AGP Epitopes in the Plastids of Aldrovanda vesiculosa: New Questions About the Distribution of These Epitopes in Angiosperms
    Bartosz J. Płachno, Małgorzata Kapusta, Marcin Feldo +3
    International journal of molecular sciencesPeer-reviewedCC BYFull textGeneral biochemistryEurope PMC
  4. SpotMAX: A generalist framework for multidimensional automatic spot detection and quantification
    Francesco Padovani, Ivana Čavka, Ana Rita Rodrigues Neves +12
    Science AdvancesPeer-reviewedCC BY-NC12 citedBiophysicsOpenAlex
  5. Design of a tetravalent dengue vaccine incorporating T-cell epitopes from NS3 and NS5 proteins and B-cell epitopes from the envelope protein using an immunoinformatics approach.
    Theerawat Dobutr, Pemikar Srifa, Nawamin Pinpathomrat
    Frontiers in cellular and infection microbiologyPeer-reviewedCC BYFull textMolecular biology & gene regulationEurope PMC

Cite

BibTeXRIS
BibTeX
@article{frieman2026conserved,
  title = {{Conserved spike epitopes persist in generalist bat sarbecoviruses}},
  author = {Matthew B. Frieman},
  journal = {PLOS Biology},
  year = {2026},
  month = oct,
  doi = {10.1371/journal.pbio.3004071},
  url = {https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3004071},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Conserved spike epitopes persist in generalist bat sarbecoviruses
AU  - Matthew B. Frieman
PY  - 2026
DA  - 2026/10/27
JO  - PLOS Biology
DO  - 10.1371/journal.pbio.3004071
UR  - https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3004071
AB  - Bat sarbecoviruses differ in the range of mammalian ACE2 receptors they can use, complicating predictions of spillover risk. Two new studies in PLOS Biology link receptor breadth with antigenic relatedness and reveal conserved spike epitopes targetable by antibodies.  Bat sarbecoviruses differ in the range of mammalian ACE2 receptors they can use, complicating predictions of spillover risk. This Primer comments on two new studies in PLOS Biology that link receptor breadth with antigenic relatedness and reveal conserved spike epitopes targetable by antibodies.
SN  - 1545-7885
SN  - 1544-9173
ER  -