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Peer-reviewedLicence not statedNature Reviews Clinical Oncology

The future is not always uniform: rethinking radiotherapy through spatial fractionation

  • Federico Iori1,2
  • Slavisa Tubin3
  • Waleed Fouad Mourad4
  • Marco Durante5,6,7
  • Yolanda Prezado8,9
  • Pedro C. Lara10,11,12
  • Andrea Botti13
  • Xiaodong Wu14,15
  • Matthias Gückenberger16
  • on behalf of the ESTRO Focus Group
  • Marco Durante5,6,7
  • Yolanda Prezado8,9
15 more authors
  • Marie‐Catherine Vozenin17
  • Kevin M. Prise18
  • Mariangela Massaccesi19
  • Pedro C. Lara10,11,12
  • Carlo Greco20
  • Marcus Stock21
  • Chanda Guha22
  • Niels Bassler23
  • Dominic Leiser24
  • Cristian Fernández25
  • Xiaodong Wu14,15
  • Daniel M. Koffler26
  • Robert J. Griffin27
  • Waleed Fouad Mourad4
  • Yat Man Tsang28
28 affiliations
  1. 1Clinical and Experimental Medicine, Department of Biomedical, Metabolic, and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy. [email protected]
  2. 2Radiation Oncology Unit, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy. [email protected]
  3. 3Universitätsklinikum Krems, Department of Radiation Oncology, Krems an der Donau, Austria
  4. 4College of Medicine, Markey Comprehensive Cancer Center, University of Kentucky, Lexington, KY, USA
  5. 5Biophysics Department, GSI Helmholtz Centre for Heavy Ion Research, Darmstadt, Germany
  6. 6Department of Physics Ettore Pancini, University Federico II, Naples, Italy
  7. 7Institute of Condensed Matter Physics, Technische Universität Darmstadt, Darmstadt, Germany
  8. 8New Approaches in Radiotherapy Lab, Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), University of Santiago de Compostela, Santiago de Compostela, Spain
  9. 9Oportunius Program, Galician Agency of Innovation (GAIN), Xunta de Galicia, Santiago de Compostela, Spain
  10. 10Canarian Comprehensive Cancer Center, Department of Oncology, University Hospital San Roque, Las Palmas de Gran Canaria, Spain
  11. 11Canarian Institute for Cancer Research, San Cristobal de La Laguna, Tenerife, Spain
  12. 12Department of Medicine, Fernando Pessoa Canarias University, Santa Maria de Guía de Gran Canaria, Spain
  13. 13Medical Physics Unit, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy
  14. 14Executive Medical Physics Associates, Miami, FL, USA
  15. 15Innovative Cancer Institute, South Miami, FL, USA
  16. 16Department of Radiation Oncology, University Hospital Zurich, University of Zurich, Zurich, Switzerland
  17. 17Hôpitaux Universitaires de Genève, Geneva, Switzerland
  18. 18Patrick G Johnston Centre for Cancer Research, Queen’s University Belfast, Belfast, UK
  19. 19Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy
  20. 20Champalimaud Foundation, Lisbon, Portugal
  21. 21MedAustron, Wiener Neustadt, Austria
  22. 22Montefiore Medical Center, Albert Einstein College of Medicine, New York, NY, USA
  23. 23Aarhus University, Aarhus, Denmark
  24. 24Paul Scherrer Institute, Villigen, Switzerland
  25. 25University of Bern, Bern, Switzerland
  26. 26Mayo Clinic, Jacksonville, FL, USA
  27. 27University of Arkansas for Medical Sciences, Little Rock, AR, USA
  28. 28Princess Margaret Cancer Centre, Toronto, Ontario, Canada
Open at sourceDOICite

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Cite

BibTeXRIS
BibTeX
@article{iori2026future,
  title = {{The future is not always uniform: rethinking radiotherapy through spatial fractionation}},
  author = {Federico Iori and Slavisa Tubin and Waleed Fouad Mourad and Marco Durante and Yolanda Prezado and Pedro C. Lara and Andrea Botti and Xiaodong Wu and Matthias Gückenberger and on behalf of the ESTRO Focus Group and Marco Durante and Yolanda Prezado and Marie‐Catherine Vozenin and Kevin M. Prise and Mariangela Massaccesi and Pedro C. Lara and Carlo Greco and Marcus Stock and Chanda Guha and Niels Bassler and Dominic Leiser and Cristian Fernández and Xiaodong Wu and Daniel M. Koffler and Robert J. Griffin and Waleed Fouad Mourad and Yat Man Tsang},
  journal = {Nature Reviews Clinical Oncology},
  year = {2026},
  month = jun,
  doi = {10.1038/s41571-026-01161-y},
  url = {https://pure.qub.ac.uk/en/publications/c4b0155d-40e8-4220-bc15-7f213ef1a37a},
}
RIS
TY  - JOUR
TI  - The future is not always uniform: rethinking radiotherapy through spatial fractionation
AU  - Federico Iori
AU  - Slavisa Tubin
AU  - Waleed Fouad Mourad
AU  - Marco Durante
AU  - Yolanda Prezado
AU  - Pedro C. Lara
AU  - Andrea Botti
AU  - Xiaodong Wu
AU  - Matthias Gückenberger
AU  - on behalf of the ESTRO Focus Group
AU  - Marco Durante
AU  - Yolanda Prezado
AU  - Marie‐Catherine Vozenin
AU  - Kevin M. Prise
AU  - Mariangela Massaccesi
AU  - Pedro C. Lara
AU  - Carlo Greco
AU  - Marcus Stock
AU  - Chanda Guha
AU  - Niels Bassler
AU  - Dominic Leiser
AU  - Cristian Fernández
AU  - Xiaodong Wu
AU  - Daniel M. Koffler
AU  - Robert J. Griffin
AU  - Waleed Fouad Mourad
AU  - Yat Man Tsang
PY  - 2026
DA  - 2026/06/10
JO  - Nature Reviews Clinical Oncology
DO  - 10.1038/s41571-026-01161-y
UR  - https://pure.qub.ac.uk/en/publications/c4b0155d-40e8-4220-bc15-7f213ef1a37a
SN  - 1759-4774
SN  - 1759-4782
ER  -