Lactotransferrin gene functional polymorphisms do not influence susceptibility to human immunodeficiency virus-1 mother-to-child transmission in different ethnic groups
Abstract
Lactotransferrin, also known as lactoferrin, is an iron binding glycoprotein that displays antiviral activity against many different infectious agents, including human immunodeficiency virus (HIV)-1. Lactotransferrin is present in the breast milk and in the female genitourinary mucosa and it has been hypothesised as a possible candidate to prevent mother-to-child HIV-1 transmission. To verify if two functional polymorphisms, Thr29Ala and Arg47Lys, in the lactotransferrin encoding gene (LTF) could affect HIV-1 infection and vertical transmission, a preliminary association study was performed in 238 HIV-1 positive and 99 HIV-1 negative children from Brazil, Italy, Africa and India. No statistically significant association for the Thr29Ala and Arg47Lys LTF polymorphisms and HIV-1 susceptibility in the studied populations was found. Additionally LTF polymorphisms frequencies were compared between the four different ethnic groups.
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BibTeX
@article{zupin2026lactotransferrin,
title = {{Lactotransferrin gene functional polymorphisms do not influence susceptibility to human immunodeficiency virus-1 mother-to-child transmission in different ethnic groups}},
author = {Luisa Zupin and Vania Polesello and Antonio Victor Campos Coelho and Michele Boniotto and Luiz Claudio Arraes and Sergio Crovella},
journal = {Memórias do Instituto Oswaldo Cruz},
year = {2026},
month = oct,
doi = {10.1590/0074-02760140447},
url = {https://hal.science/hal-05797369v1},
note = {CC BY-NC},
}
RIS
TY - JOUR
TI - Lactotransferrin gene functional polymorphisms do not influence susceptibility to human immunodeficiency virus-1 mother-to-child transmission in different ethnic groups
AU - Luisa Zupin
AU - Vania Polesello
AU - Antonio Victor Campos Coelho
AU - Michele Boniotto
AU - Luiz Claudio Arraes
AU - Sergio Crovella
PY - 2026
DA - 2026/10/13
JO - Memórias do Instituto Oswaldo Cruz
DO - 10.1590/0074-02760140447
UR - https://hal.science/hal-05797369v1
AB - Lactotransferrin, also known as lactoferrin, is an iron binding glycoprotein that displays antiviral activity against many different infectious agents, including human immunodeficiency virus (HIV)-1. Lactotransferrin is present in the breast milk and in the female genitourinary mucosa and it has been hypothesised as a possible candidate to prevent mother-to-child HIV-1 transmission. To verify if two functional polymorphisms, Thr29Ala and Arg47Lys, in the lactotransferrin encoding gene (LTF) could affect HIV-1 infection and vertical transmission, a preliminary association study was performed in 238 HIV-1 positive and 99 HIV-1 negative children from Brazil, Italy, Africa and India. No statistically significant association for the Thr29Ala and Arg47Lys LTF polymorphisms and HIV-1 susceptibility in the studied populations was found. Additionally LTF polymorphisms frequencies were compared between the four different ethnic groups.
SN - 0074-0276
SN - 1678-8060
ER -