Skip to content
DraconiticResearch
Search Sources API
203,203 studies31 sourcesUpdated 10 min ago
Peer-reviewedCC BY 4.0PLOS One

Impact of GST and TP53 gene polymorphisms on susceptibility to end stage renal disease: A case-control analysis

  • Rashid Mehmood1
  • Pei-Chun Chiang2
  • Madiha Rasool3
  • Muhammad Asif4
  • Abdul Ghafar5
  • Mustansar Khalid6
  • Saba Razaq7
  • Muhammad Khaleeq Alam8
  • Iram Fatima9
  • Iqra Jabeen10
  • Sehrish Ashraf
  • Furhan Iqbal
1 more authors
  • Chien-Chin Chen
10 affiliations
  1. 1Institute of Zoology, Bahauddin Zakariya University, Multan, Pakistan
  2. 2Division of Nephrology, Department of Internal Medicine, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi, Taiwan
  3. 3Department of Zoology, The Women University Multan, Multan, Pakistan
  4. 4Department of Nephrology, Allama Iqbal Teaching Hospital, Dera Ghazi Khan, Pakistan
  5. 5Department of Zoology, Ghazi University, Dera Ghazi Khan, Pakistan
  6. 6Department of Zoology, Emerson University Multan, Multan, Pakistan
  7. 7Department of Pathology, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi, Taiwan
  8. 8Department of Cosmetic Science, Chia Nan University of Pharmacy and Science, Tainan, Taiwan
  9. 9Doctoral Program in Translational Medicine, National Chung Hsing University, Taichung, Taiwan
  10. 10Department of Biotechnology and Bioindustry Sciences, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan, Taiwan
Open at sourcePDFDOICite

Abstract

Purpose: End-stage renal disease (ESRD) is a major global non-communicable condition associated with substantial morbidity and mortality. The current investigation aimed to report the association of GSTM1, GSTT1 genotypes and single nucleotide polymorphisms (SNPs) in GSTP1 (rs1695) and TP53 (rs1042522) genes with ESRD. Methods: Clinically confirmed ESRD patients (n = 305) and healthy controls (n = 305) were enrolled from District Multan in Punjab, Pakistan, during 30-10-2023 till 28-02-2024, following their informed verbal consent. Multiplex and T-ARMS PCR based approaches were used to document the genotype at GSTs and SNPs of targeted genes and their associations with ESRD were analyzed individually as well as in combination. Results: A significant association of absence of GSTM1, presence of GSTT1, presence of “G” polymorphic allele at rs1695 in GSTP1, and the presence of “C” polymorphic allele at rs1042522 in TP53 gene was observed with ESRD during the present study. Participants having age ranging between 26–40 years, males and smokers suffered more from ESRD. Conclusion: Genetic variations in the studied GSTs, along with rs1695 in GSTP1 and rs1042522 in the TP53 gene, may influence the progression of ESRD.

Related

  1. Association of MDM2 rs2279744 and rs937282 polymorphisms with breast cancer susceptibility and circulating MDM2 and p53 levels in Bangladeshi women: A case-control study
    Mahim Hassan Chowdhury, Farzana Islam, Adiba Ayesha Khan +8
    PLOS OnePeer-reviewedCC BY 4.0Full textGenetics & genomicsPLOS
  2. Association between H19 polymorphisms and susceptibility to pediatric central nervous system tumors in Chinese children
    Wei Chen, Jinhong Zhu, Xiaokai Huang +3
    Scientific ReportsPeer-reviewedCC BY-NC-ND 4.0Full textGenetics & genomicsCrossref
  3. Lactotransferrin gene functional polymorphisms do not influence susceptibility to human immunodeficiency virus-1 mother-to-child transmission in different ethnic groups
    Luisa Zupin, Vania Polesello, Antonio Victor Campos Coelho +3
    Memórias do Instituto Oswaldo CruzPeer-reviewedCC BY-NCFull text6 citedMicrobiologyHAL
  4. Association of regulatory B, T cells and cytokine production with disease stage in non-small cell lung cancer patients: prospective case control study.
    Helal F Hetta, Asmaa M Zahran, Emad Eldin Nabil +11
    BMC cancerPeer-reviewedCC BY-NC-NDFull textImmunologyEurope PMC
  5. Association of SDF-1β (rs1801157) and TCF7L2 (rs12255372) Gene Polymorphisms With Type 2 Diabetes Mellitus in the Bangladeshi Population: A Case-Control Study.
    Md Abdullah Al Mobin, Shahriar Alam Shanto, Eamin Hasnayan +9
    Health science reportsPeer-reviewedCC BY-NC-NDFull textGenetics & genomicsEurope PMCDOAJ

Cite

BibTeXRIS
BibTeX
@article{mehmood2026impact,
  title = {{Impact of GST and TP53 gene polymorphisms on susceptibility to end stage renal disease: A case-control analysis}},
  author = {Rashid Mehmood and Pei-Chun Chiang and Madiha Rasool and Muhammad Asif and Abdul Ghafar and Mustansar Khalid and Saba Razaq and Muhammad Khaleeq Alam and Iram Fatima and Iqra Jabeen and Sehrish Ashraf and Furhan Iqbal and Chien-Chin Chen},
  journal = {PLOS One},
  year = {2026},
  month = oct,
  doi = {10.1371/journal.pone.0359809},
  url = {https://doi.org/10.1371/journal.pone.0359809},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Impact of GST and TP53 gene polymorphisms on susceptibility to end stage renal disease: A case-control analysis
AU  - Rashid Mehmood
AU  - Pei-Chun Chiang
AU  - Madiha Rasool
AU  - Muhammad Asif
AU  - Abdul Ghafar
AU  - Mustansar Khalid
AU  - Saba Razaq
AU  - Muhammad Khaleeq Alam
AU  - Iram Fatima
AU  - Iqra Jabeen
AU  - Sehrish Ashraf
AU  - Furhan Iqbal
AU  - Chien-Chin Chen
PY  - 2026
DA  - 2026/10/05
JO  - PLOS One
DO  - 10.1371/journal.pone.0359809
UR  - https://doi.org/10.1371/journal.pone.0359809
AB  - Purpose: End-stage renal disease (ESRD) is a major global non-communicable condition associated with substantial morbidity and mortality. The current investigation aimed to report the association of GSTM1, GSTT1 genotypes and single nucleotide polymorphisms (SNPs) in GSTP1 (rs1695) and TP53 (rs1042522) genes with ESRD. Methods: Clinically confirmed ESRD patients (n = 305) and healthy controls (n = 305) were enrolled from District Multan in Punjab, Pakistan, during 30-10-2023 till 28-02-2024, following their informed verbal consent. Multiplex and T-ARMS PCR based approaches were used to document the genotype at GSTs and SNPs of targeted genes and their associations with ESRD were analyzed individually as well as in combination. Results: A significant association of absence of GSTM1, presence of GSTT1, presence of “G” polymorphic allele at rs1695 in GSTP1, and the presence of “C” polymorphic allele at rs1042522 in TP53 gene was observed with ESRD during the present study. Participants having age ranging between 26–40 years, males and smokers suffered more from ESRD. Conclusion: Genetic variations in the studied GSTs, along with rs1695 in GSTP1 and rs1042522 in the TP53 gene, may influence the progression of ESRD.
SN  - 1932-6203
ER  -