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Peer-reviewedCC BY-NCCell Reports

Clustered inputs engage dendritic nonlinearities and calcium signaling to support efficient place-field formation in CA1 pyramidal neurons

  • Simone Tasciotti1
  • Daniel Maxim Iascone2
  • Spyridon Chavlis3
  • Luke Alexander Hammond2
  • Yardena Katz2
  • Attila Losonczy4
  • Franck Polleux4
  • Panayiota Poirazi5
5 affiliations
  1. 1Department of Biology, University of Crete, Heraklion, Greece; Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Heraklion, Greece
  2. 2Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA
  3. 3Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Heraklion, Greece
  4. 4Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA; Department of Neuroscience, Columbia University, New York, NY, USA
  5. 5Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Heraklion, Greece. Electronic address: [email protected]
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Abstract

The synaptic mechanisms driving feature selectivity in specific neuron types remains a fundamental and unresolved challenge in neuroscience. In hippocampal CA1 pyramidal neurons (PNs), the development of place selectivity, manifested as place fields, is believed to result from dendritic integration of spatially distributed inputs combined with behavioral time scale plasticity (BTSP). BTSP involves dendritic spikes that temporally regulate synaptic potentiation and depotentiation. However, the role of excitatory (E) and inhibitory (I) synaptic distributions in the emergence of place specificity in CA1 PNs remains unclear, due to the lack of detailed synaptic reconstructions in vivo. Here, we present full synaptic reconstructions from individual CA1 PNs in the mouse hippocampus, revealing that these neurons receive approximately 10,000-15,000 E synapses and 900-1,400 I synapses. Computational modeling of biologically relevant E and I synaptic distributions shows that spatial tuning is preserved with co-tuned, spatially clustered E synapses, but disrupted when E distributions are randomized. Moreover, synapse clustering has a different contribution to spatial tuning in apical vs. basal domains. Our results reveal a complex and finely-tuned interplay between presynaptic input patterns and the spatial organization of their postsynaptic targets in dictating neuronal output in CA1 PNs.

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Cite

BibTeXRIS
BibTeX
@article{tasciotti2026clustered,
  title = {{Clustered inputs engage dendritic nonlinearities and calcium signaling to support efficient place-field formation in CA1 pyramidal neurons}},
  author = {Simone Tasciotti and Daniel Maxim Iascone and Spyridon Chavlis and Luke Alexander Hammond and Yardena Katz and Attila Losonczy and Franck Polleux and Panayiota Poirazi},
  journal = {Cell Reports},
  year = {2026},
  month = aug,
  doi = {10.1016/j.celrep.2026.117793},
  url = {https://doi.org/10.1016/j.celrep.2026.117793},
  note = {CC BY-NC},
}
RIS
TY  - JOUR
TI  - Clustered inputs engage dendritic nonlinearities and calcium signaling to support efficient place-field formation in CA1 pyramidal neurons
AU  - Simone Tasciotti
AU  - Daniel Maxim Iascone
AU  - Spyridon Chavlis
AU  - Luke Alexander Hammond
AU  - Yardena Katz
AU  - Attila Losonczy
AU  - Franck Polleux
AU  - Panayiota Poirazi
PY  - 2026
DA  - 2026/08/01
JO  - Cell Reports
DO  - 10.1016/j.celrep.2026.117793
UR  - https://doi.org/10.1016/j.celrep.2026.117793
AB  - The synaptic mechanisms driving feature selectivity in specific neuron types remains a fundamental and unresolved challenge in neuroscience. In hippocampal CA1 pyramidal neurons (PNs), the development of place selectivity, manifested as place fields, is believed to result from dendritic integration of spatially distributed inputs combined with behavioral time scale plasticity (BTSP). BTSP involves dendritic spikes that temporally regulate synaptic potentiation and depotentiation. However, the role of excitatory (E) and inhibitory (I) synaptic distributions in the emergence of place specificity in CA1 PNs remains unclear, due to the lack of detailed synaptic reconstructions in vivo. Here, we present full synaptic reconstructions from individual CA1 PNs in the mouse hippocampus, revealing that these neurons receive approximately 10,000-15,000 E synapses and 900-1,400 I synapses. Computational modeling of biologically relevant E and I synaptic distributions shows that spatial tuning is preserved with co-tuned, spatially clustered E synapses, but disrupted when E distributions are randomized. Moreover, synapse clustering has a different contribution to spatial tuning in apical vs. basal domains. Our results reveal a complex and finely-tuned interplay between presynaptic input patterns and the spatial organization of their postsynaptic targets in dictating neuronal output in CA1 PNs.
SN  - 2211-1247
SN  - 2639-1856
ER  -