Surface Functionalization of Halloysite Nanotubes with Poly(acrylic acid) and Evaluation of Their Hemostatic Activity
5 affiliations
- 1Yildiz Technical University , , , ,
- 2YTÜ, MÜ, IÜC Health Biotechnology Excellence Joint Research and Application Center , , ,
- 3Baku State University , , ,
- 4Istanbul Technical University , , Maslak, Sariyer, ,
- 5Istanbul University-Cerrahpaşa , , ,
Abstract
Clays are widely used functional materials in industrial production due to their low cost, diversity, and easy accessibility. Since clays generally exhibit limited compatibility with other molecules, surface functionalization is often employed to modify their properties and expand their potential applications, particularly in biomaterials research. In this study, the potential of halloysite nanotubes (HNTs) as hemostatic materials was investigated by modifying their surface properties via photoinduced polymerization of acrylic acid (AA). PAA was coated onto MAPTES-silanized HNT substrates to enrich functional groups and modify the surface properties of the clay. The polymerization process was conducted at different polymerization times and MAPTES ratios to modulate the overall organic coating content on the HNT substrate. The structure–property relationships of the synthesized composites were comprehensively characterized, and their in vitro coagulation and platelet-recovery behaviors were evaluated. The results revealed that PAA modification altered the coagulation behavior of HNTs, resulting in changes in PT and aPTT responses that depended on the modification conditions. Furthermore, PAA modification altered the extent of platelet depletion from the recoverable plasma fraction compared with unmodified HNTs. These findings suggest that PAA modification influences the interaction between HNTs and blood components and provides a tunable surface-modification strategy, suggesting that PAA modification can modulate HNT–blood component interactions. Further studies using whole-blood and in vivo models are required to establish the hemocompatibility and hemostatic performance of the modified materials.
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BibTeX
@article{deren2026surface,
title = {{Surface Functionalization of Halloysite Nanotubes with Poly(acrylic acid) and Evaluation of Their Hemostatic Activity}},
author = {Kader Deren and Ceren Keçeciler-Emir and Cem Özel and Rasim Alosmanov and Muhammet U. Kahveci and Tuǧrul Elverdi and Sevil Yücel},
journal = {ACS Omega},
year = {2026},
month = oct,
doi = {10.1021/acsomega.6c05088},
url = {https://pubs.acs.org/acsodf/article/11/41/63191/5448476/Surface-Functionalization-of-Halloysite-Nanotubes},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Surface Functionalization of Halloysite Nanotubes with Poly(acrylic acid) and Evaluation of Their Hemostatic Activity
AU - Kader Deren
AU - Ceren Keçeciler-Emir
AU - Cem Özel
AU - Rasim Alosmanov
AU - Muhammet U. Kahveci
AU - Tuǧrul Elverdi
AU - Sevil Yücel
PY - 2026
DA - 2026/10/10
JO - ACS Omega
DO - 10.1021/acsomega.6c05088
UR - https://pubs.acs.org/acsodf/article/11/41/63191/5448476/Surface-Functionalization-of-Halloysite-Nanotubes
AB - Clays are widely used functional materials in industrial production due to their low cost, diversity, and easy accessibility. Since clays generally exhibit limited compatibility with other molecules, surface functionalization is often employed to modify their properties and expand their potential applications, particularly in biomaterials research. In this study, the potential of halloysite nanotubes (HNTs) as hemostatic materials was investigated by modifying their surface properties via photoinduced polymerization of acrylic acid (AA). PAA was coated onto MAPTES-silanized HNT substrates to enrich functional groups and modify the surface properties of the clay. The polymerization process was conducted at different polymerization times and MAPTES ratios to modulate the overall organic coating content on the HNT substrate. The structure–property relationships of the synthesized composites were comprehensively characterized, and their in vitro coagulation and platelet-recovery behaviors were evaluated. The results revealed that PAA modification altered the coagulation behavior of HNTs, resulting in changes in PT and aPTT responses that depended on the modification conditions. Furthermore, PAA modification altered the extent of platelet depletion from the recoverable plasma fraction compared with unmodified HNTs. These findings suggest that PAA modification influences the interaction between HNTs and blood components and provides a tunable surface-modification strategy, suggesting that PAA modification can modulate HNT–blood component interactions. Further studies using whole-blood and in vivo models are required to establish the hemocompatibility and hemostatic performance of the modified materials.
SN - 2470-1343
ER -