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Peer-reviewedCC BYJPGN reports

Beyond the gut: Non-specific interstitial pneumonia in pediatric ulcerative colitis-A rare extra-intestinal manifestation.

  • Harshit Vachher1
  • Vishrutha Poojari1
  • Shivangi Tetarbe1
  • Parmarth Chandane2
  • Lakshmi Shobhavat3
  • Ira Shah1
  1. 1Department of Pediatric Gastroenterology and Hepatology Bai Jerbai Wadia Hospital for Children Mumbai Maharashtra India.
  2. 2Department of Pediatric Respiratory Medicine Bai Jerbai Wadia Hospital for Children Mumbai Maharashtra India.
  3. 3Department of Pediatric Critical Care Bai Jerbai Wadia Hospital for Children Mumbai Maharashtra India.
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Abstract

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder often presenting with extra-intestinal manifestations (EIMs) involving the skin, joints and eyes. However, pulmonary manifestation, such as interstitial lung disease (ILD), is a rare complication, particularly in the pediatric population. We report a case of a 10-year-old boy, with very early onset IBD-ulcerative colitis, presented with non-productive cough, fever and dyspnea, with examination findings revealing respiratory distress, pallor, clubbing and pyoderma gangrenosum. High-resolution computed tomography (HRCT) was suggestive of bilateral diffuse ground-glass opacities with intralobular septal thickening and tractional bronchiectasis, consistent with non-specific interstitial pneumonia (NSIP). Furthermore, the patient developed septic shock and macrophage activation syndrome, requiring intensive care management and immunosuppression. This case highlights that even in the setting of silent intestinal disease activity of a pediatric IBD case, the patient can have potentially life-threatening pulmonary EIMs, warranting early diagnosis and treatment.

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Cite

BibTeXRIS
BibTeX
@article{vachher2026beyond,
  title = {{Beyond the gut: Non-specific interstitial pneumonia in pediatric ulcerative colitis-A rare extra-intestinal manifestation.}},
  author = {Harshit Vachher and Vishrutha Poojari and Shivangi Tetarbe and Parmarth Chandane and Lakshmi Shobhavat and Ira Shah},
  journal = {JPGN reports},
  year = {2026},
  month = nov,
  doi = {10.1002/jpr3.70289},
  url = {https://europepmc.org/article/MED/42996657},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Beyond the gut: Non-specific interstitial pneumonia in pediatric ulcerative colitis-A rare extra-intestinal manifestation.
AU  - Harshit Vachher
AU  - Vishrutha Poojari
AU  - Shivangi Tetarbe
AU  - Parmarth Chandane
AU  - Lakshmi Shobhavat
AU  - Ira Shah
PY  - 2026
DA  - 2026/11/05
JO  - JPGN reports
DO  - 10.1002/jpr3.70289
UR  - https://europepmc.org/article/MED/42996657
AB  - Inflammatory bowel disease (IBD) is a chronic inflammatory disorder often presenting with extra-intestinal manifestations (EIMs) involving the skin, joints and eyes. However, pulmonary manifestation, such as interstitial lung disease (ILD), is a rare complication, particularly in the pediatric population. We report a case of a 10-year-old boy, with very early onset IBD-ulcerative colitis, presented with non-productive cough, fever and dyspnea, with examination findings revealing respiratory distress, pallor, clubbing and pyoderma gangrenosum. High-resolution computed tomography (HRCT) was suggestive of bilateral diffuse ground-glass opacities with intralobular septal thickening and tractional bronchiectasis, consistent with non-specific interstitial pneumonia (NSIP). Furthermore, the patient developed septic shock and macrophage activation syndrome, requiring intensive care management and immunosuppression. This case highlights that even in the setting of silent intestinal disease activity of a pediatric IBD case, the patient can have potentially life-threatening pulmonary EIMs, warranting early diagnosis and treatment.
SN  - 2691-171X
ER  -