Neuronal IRE-1 coordinates an organism-wide cold stress response by regulating fat metabolism
Abstract
Cold affects many aspects of biology, medicine, agriculture, and industry. Here, we identify a conserved endoplasmic reticulum (ER) stress response, distinct from the canonical unfolded protein response, that maintains lipid homeostasis during extreme cold. We establish that the ER stress sensor IRE-1 is critical for resistance to extreme cold and activated by cold temperature. Specifically, neuronal IRE-1 signals through JNK-1 and neuropeptide signaling to regulate lipid composition within the animal. This cold-response pathway can be bypassed by dietary supplementation with unsaturated fatty acids. Altogether, our findings define an ER-centric conserved organism-wide cold stress response, consisting of molecular neuronal sensors, effectors, and signaling moieties, which control adaptation to cold conditions in the organism. Better understanding of the molecular basis of this stress response is crucial for the optimal use of cold conditions on live organisms and manipulation of lipid saturation homeostasis, which is perturbed in human pathologies.
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BibTeX
@article{dudkevich2026neuronal,
title = {{Neuronal IRE-1 coordinates an organism-wide cold stress response by regulating fat metabolism}},
author = {Reut Dudkevich and Jhee Hong Koh and Caroline Beaudoin-Chabot and Cenk Celik and Ilana Lebenthal-Loinger and Sarit Karako-Lampert and Syed Ahmad-Albukhari and Guillaume Thibault and Sivan Henis-Korenblit},
journal = {Cell Reports},
year = {2026},
month = sep,
doi = {10.1016/j.celrep.2022.111739},
url = {https://hal.science/hal-05770378v1},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Neuronal IRE-1 coordinates an organism-wide cold stress response by regulating fat metabolism
AU - Reut Dudkevich
AU - Jhee Hong Koh
AU - Caroline Beaudoin-Chabot
AU - Cenk Celik
AU - Ilana Lebenthal-Loinger
AU - Sarit Karako-Lampert
AU - Syed Ahmad-Albukhari
AU - Guillaume Thibault
AU - Sivan Henis-Korenblit
PY - 2026
DA - 2026/09/30
JO - Cell Reports
DO - 10.1016/j.celrep.2022.111739
UR - https://hal.science/hal-05770378v1
AB - Cold affects many aspects of biology, medicine, agriculture, and industry. Here, we identify a conserved endoplasmic reticulum (ER) stress response, distinct from the canonical unfolded protein response, that maintains lipid homeostasis during extreme cold. We establish that the ER stress sensor IRE-1 is critical for resistance to extreme cold and activated by cold temperature. Specifically, neuronal IRE-1 signals through JNK-1 and neuropeptide signaling to regulate lipid composition within the animal. This cold-response pathway can be bypassed by dietary supplementation with unsaturated fatty acids. Altogether, our findings define an ER-centric conserved organism-wide cold stress response, consisting of molecular neuronal sensors, effectors, and signaling moieties, which control adaptation to cold conditions in the organism. Better understanding of the molecular basis of this stress response is crucial for the optimal use of cold conditions on live organisms and manipulation of lipid saturation homeostasis, which is perturbed in human pathologies.
SN - 2211-1247
SN - 2211-1247
ER -