Multimodal MRI of choroid plexus volume, DTI-ALPS, and white matter microstructure in type 2 diabetes mellitus.
- 1Fuzong Teaching Hospital of Fujian University of Traditional Chinese Medicine (900th Hospital), Fujian, Fuzhou, China.
- 2Department of Radiology, 900th Hospital of PLA Joint Logistic Support Force, Fujian, Fuzhou, China.
- 3College of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fujian, Fuzhou, China.
Abstract
Objective
To investigate differences in choroid plexus volume (CPV), diffusion tensor image analysis along the perivascular space (DTI-ALPS) indices, peak width of skeletonized mean diffusivity (PSMD), and Mini-Mental State Examination (MMSE) scores between patients with type 2 diabetes mellitus (T2DM) and healthy controls, and to explore pairwise associations among diabetes duration, PSMD, normalized total CPV, total DTI-ALPS, and MMSE within the T2DM group.Methods
This retrospective cross-sectional study included 31 patients with T2DM and 31 healthy controls (HCs). All participants underwent 3.0-T MRI and MMSE assessment. General linear models were used to compare normalized CPV, DTI-ALPS indices, PSMD, and MMSE scores between groups, adjusting for age, sex, body mass index, and years of education. Within the T2DM group, exploratory partial correlations were performed among diabetes duration, PSMD, normalized total CPV, total DTI-ALPS, and MMSE, controlling for the same covariates. The resulting 10 pairwise associations were corrected together using the Benjamini-Hochberg false discovery rate (FDR) procedure.Results
Compared with HCs, patients with T2DM showed greater normalized total and bilateral CPV, lower total DTI-ALPS, higher PSMD, and lower MMSE scores (all PFDR < 0.05). Among the 10 exploratory associations, only the positive association between diabetes duration and PSMD remained significant after FDR correction (partial r = 0.566, P = 0.002, PFDR = 0.021). The inverse association between normalized total CPV and total DTI-ALPS was nominally significant (partial r = -0.412, P = 0.033) but did not survive FDR correction (PFDR = 0.163).Conclusion
Patients with T2DM showed differences in CPV, DTI-ALPS, PSMD, and MMSE scores. Longer diabetes duration was associated with higher PSMD after FDR correction, whereas the CPV-DTI-ALPS association did not survive multiple-comparison correction. These findings highlight the value of multimodal MRI for characterizing brain involvement in T2DM.
Related
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- Prenatal MRI quantitative analysis of the nonlinear morphological changes of the choroid plexus during the progression of fetal ventriculomegaly
- Age-related molecular and functional remodeling of the choroid plexus in the gray mouse lemur
- Choroid plexus asymmetry on routine MRI as an imaging signature of breast cancer brain metastasis
- Choroid plexus volume variation in patients with gliomas, glioneuronal and neuronal tumors: Associations with tumor characteristics
BibTeX
@article{mao2026multimodal,
title = {{Multimodal MRI of choroid plexus volume, DTI-ALPS, and white matter microstructure in type 2 diabetes mellitus.}},
author = {Minghui Mao and Linghan Chen and Juan Xia and Taipeng Zeng and Hao Huang and Jianfeng Chu and Liyuan Fu},
journal = {Frontiers in medicine},
year = {2026},
month = oct,
doi = {10.3389/fmed.2026.1968119},
url = {https://europepmc.org/article/MED/42908669},
note = {CC BY},
}
RIS
TY - JOUR
TI - Multimodal MRI of choroid plexus volume, DTI-ALPS, and white matter microstructure in type 2 diabetes mellitus.
AU - Minghui Mao
AU - Linghan Chen
AU - Juan Xia
AU - Taipeng Zeng
AU - Hao Huang
AU - Jianfeng Chu
AU - Liyuan Fu
PY - 2026
DA - 2026/10/07
JO - Frontiers in medicine
DO - 10.3389/fmed.2026.1968119
UR - https://europepmc.org/article/MED/42908669
AB - Objective To investigate differences in choroid plexus volume (CPV), diffusion tensor image analysis along the perivascular space (DTI-ALPS) indices, peak width of skeletonized mean diffusivity (PSMD), and Mini-Mental State Examination (MMSE) scores between patients with type 2 diabetes mellitus (T2DM) and healthy controls, and to explore pairwise associations among diabetes duration, PSMD, normalized total CPV, total DTI-ALPS, and MMSE within the T2DM group.Methods This retrospective cross-sectional study included 31 patients with T2DM and 31 healthy controls (HCs). All participants underwent 3.0-T MRI and MMSE assessment. General linear models were used to compare normalized CPV, DTI-ALPS indices, PSMD, and MMSE scores between groups, adjusting for age, sex, body mass index, and years of education. Within the T2DM group, exploratory partial correlations were performed among diabetes duration, PSMD, normalized total CPV, total DTI-ALPS, and MMSE, controlling for the same covariates. The resulting 10 pairwise associations were corrected together using the Benjamini-Hochberg false discovery rate (FDR) procedure.Results Compared with HCs, patients with T2DM showed greater normalized total and bilateral CPV, lower total DTI-ALPS, higher PSMD, and lower MMSE scores (all PFDR < 0.05). Among the 10 exploratory associations, only the positive association between diabetes duration and PSMD remained significant after FDR correction (partial r = 0.566, P = 0.002, PFDR = 0.021). The inverse association between normalized total CPV and total DTI-ALPS was nominally significant (partial r = -0.412, P = 0.033) but did not survive FDR correction (PFDR = 0.163).Conclusion Patients with T2DM showed differences in CPV, DTI-ALPS, PSMD, and MMSE scores. Longer diabetes duration was associated with higher PSMD after FDR correction, whereas the CPV-DTI-ALPS association did not survive multiple-comparison correction. These findings highlight the value of multimodal MRI for characterizing brain involvement in T2DM.
SN - 2296-858X
ER -