Global Postural Reeducation in Mild Alzheimer’s Disease: A Secondary Analysis of an RCT
- 1ÍTEM – Innovation in Manual and Physical Therapies, Research Group, Physiotherapy Department, UCAM Universidad Católica San Antonio de Murcia, Murcia, Spain
Abstract
Background: Depression and neuropsychiatric symptoms are common in Alzheimer’s disease (AD) and may contribute to functional decline and reduced quality of life.
Methods: This secondary analysis used data from a randomized controlled trial (NCT03732053). Fifty-eight participants were analyzed: 36 received supervised GPR twice weekly for 24 weeks and 22 received usual care. Outcomes included the Geriatric Depression Scale (GDS), Neuropsychiatric Inventory (NPI), Mini-Mental State Examination (MMSE), Barthel Index, and Performance-Oriented Mobility Assessment (POMA). Repeated-measures ANOVA and baseline-adjusted analyses were performed.
Results: At 24 weeks, GDS scores were lower with GPR than usual care (4.72 ± 2.36 vs. 8.41 ± 2.15; p < 0.001). Significant group × time effects were observed for NPI, MMSE, Barthel Index, and POMA (all p < 0.001).
Conclusion: GPR may provide complementary benefits across psychological, cognitive, and functional outcomes in mild AD, although baseline imbalance and differential attrition warrant cautious interpretation.
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BibTeX
@article{lena2026global,
title = {{Global Postural Reeducation in Mild Alzheimer’s Disease: A Secondary Analysis of an RCT}},
author = {Orges Lena and Jasemin Todri},
journal = {American Journal of Alzheimer's Disease and Other Dementias},
year = {2026},
month = sep,
doi = {10.1177/15333175261489372},
url = {https://doi.org/10.1177/15333175261489372},
note = {CC BY-NC 4.0},
}
RIS
TY - JOUR
TI - Global Postural Reeducation in Mild Alzheimer’s Disease: A Secondary Analysis of an RCT
AU - Orges Lena
AU - Jasemin Todri
PY - 2026
DA - 2026/09/18
JO - American Journal of Alzheimer's Disease and Other Dementias
DO - 10.1177/15333175261489372
UR - https://doi.org/10.1177/15333175261489372
AB - Background: Depression and neuropsychiatric symptoms are common in Alzheimer’s disease (AD) and may contribute to functional decline and reduced quality of life. Methods: This secondary analysis used data from a randomized controlled trial (NCT03732053). Fifty-eight participants were analyzed: 36 received supervised GPR twice weekly for 24 weeks and 22 received usual care. Outcomes included the Geriatric Depression Scale (GDS), Neuropsychiatric Inventory (NPI), Mini-Mental State Examination (MMSE), Barthel Index, and Performance-Oriented Mobility Assessment (POMA). Repeated-measures ANOVA and baseline-adjusted analyses were performed. Results: At 24 weeks, GDS scores were lower with GPR than usual care (4.72 ± 2.36 vs. 8.41 ± 2.15; p < 0.001). Significant group × time effects were observed for NPI, MMSE, Barthel Index, and POMA (all p < 0.001). Conclusion: GPR may provide complementary benefits across psychological, cognitive, and functional outcomes in mild AD, although baseline imbalance and differential attrition warrant cautious interpretation.
SN - 1533-3175
SN - 1938-2731
ER -