Skip to content
DraconiticResearch
Search Sources API
197,787 studies31 sourcesUpdated 18 min ago
Peer-reviewedCC BYReports (MDPI)

Isolated Thyroid Metastasis from High-Grade Clear Cell Renal Cell Carcinoma After Radical Nephrectomy: A Case Report.

  • Constantinos Papadopoulos1,2
  • Konstantina Dinaki2,3
  • Rafail Ioannidis2,4
  • Ioanna Gravalidou5
  • Anna Zisi2
5 affiliations
  1. 1Department of ENT Surgery, General Hospital of Drama, 66132 Drama, Greece.
  2. 2Medical School, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
  3. 3Department of ENT Surgery, General Hospital of Mytilene 'Vostaneio', 81132 Mytilene, Greece.
  4. 4Department of Anesthesiology and Pain Medicine, General Hospital of Drama, 66132 Drama, Greece.
  5. 5Department of General Surgery, Landesspital Liechtenstein, FL-9490 Vaduz, Liechtenstein.
Read full textPDFDOICite

Abstract

Background and Clinical Significance: Thyroid metastasis from clear cell renal cell carcinoma (ccRCC) is uncommon and may occur after radical nephrectomy despite no evidence of residual or metastatic disease at that time. Diagnosis can be challenging because imaging and fine-needle aspiration (FNA) may mimic benign or primary thyroid lesions. Case Presentation: A 55-year-old man underwent left radical nephrectomy for WHO/ISUP grade 3 ccRCC with focal grade 4 differentiation. Two years later, surveillance ultrasonography detected a suspicious lesion involving the thyroid isthmus and left lobe. FNA was interpreted as Bethesda II (benign), but metastatic ccRCC was subsequently confirmed after total thyroidectomy. Histopathology showed focal vascular and capsular invasion. Tumor reached the margin of the main thyroid specimen, whereas separately submitted perithyroidal soft tissue had tumor-free margins, resulting in a final R0 resection. The tumor was positive for CK8/18, PAX8, EMA, vimentin, and CD10 and negative for TTF-1, thyroglobulin, calcitonin, and CD5. Postoperative 18F-FDG PET/CT showed no additional metastatic disease. Conclusions: Benign thyroid cytology should be interpreted cautiously in patients with previous ccRCC when clinical or imaging findings remain suspicious. Diagnosis requires integration of oncological history, imaging, histopathology, and immunohistochemistry. Surgical resection may provide local disease control in selected patients, with surveillance.

Related

  1. Case Report: Metachronous colon metastasis of clear-cell renal cell carcinoma seven years after radical nephrectomy
    Yuhang Tian, Xinchun Wu, Yongbai Li +4
    Frontiers in OncologyPeer-reviewedCC BY 4.0Full textOncologyCrossref
  2. Recognizing a duplicated inferior vena cava during radical nephrectomy for papillary renal cell carcinoma: A case report
    Muhammad Wajid Siddique, Muhammad Waqas, Muhammad Hanzla Shahzad +2
    Urology Case ReportsPeer-reviewedCC BYFull textOncologyDOAJEurope PMCPMC
  3. Delayed sequential lung, acral cutaneous and brain metastases after radical nephrectomy for clear cell renal cell carcinoma: a case report
    Péter Álmos Rajhóczki, Viktor Kardos, Rézan Watti +4
    Frontiers in OncologyPeer-reviewedCC BY 4.0Full textOncologyCrossrefEurope PMCPMCEurope PMC
  4. Late isolated renal fossa recurrence of clear cell renal cell carcinoma 15 Years post-nephrectomy: A case report and literature review.
    Hamid Shafi, Ali Asghar Rezaei, Hassan Younesi +3
    Caspian journal of internal medicinePeer-reviewedCC BY-NCFull textGeneral medicineEurope PMC
  5. Treatment strategies for unilateral papillary thyroid carcinoma with ipsilateral cervical lymph node metastasis: a narrative review
    Gland SurgeryPeer-reviewedCC BY-NC-NDFull textGeneral medicineEurope PMC

Cite

BibTeXRIS
BibTeX
@article{papadopoulos2026isolated,
  title = {{Isolated Thyroid Metastasis from High-Grade Clear Cell Renal Cell Carcinoma After Radical Nephrectomy: A Case Report.}},
  author = {Constantinos Papadopoulos and Konstantina Dinaki and Rafail Ioannidis and Ioanna Gravalidou and Anna Zisi},
  journal = {Reports (MDPI)},
  year = {2026},
  month = oct,
  doi = {10.3390/reports9040346},
  url = {https://europepmc.org/article/MED/42924798},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Isolated Thyroid Metastasis from High-Grade Clear Cell Renal Cell Carcinoma After Radical Nephrectomy: A Case Report.
AU  - Constantinos Papadopoulos
AU  - Konstantina Dinaki
AU  - Rafail Ioannidis
AU  - Ioanna Gravalidou
AU  - Anna Zisi
PY  - 2026
DA  - 2026/10/12
JO  - Reports (MDPI)
DO  - 10.3390/reports9040346
UR  - https://europepmc.org/article/MED/42924798
AB  - Background and Clinical Significance: Thyroid metastasis from clear cell renal cell carcinoma (ccRCC) is uncommon and may occur after radical nephrectomy despite no evidence of residual or metastatic disease at that time. Diagnosis can be challenging because imaging and fine-needle aspiration (FNA) may mimic benign or primary thyroid lesions. Case Presentation: A 55-year-old man underwent left radical nephrectomy for WHO/ISUP grade 3 ccRCC with focal grade 4 differentiation. Two years later, surveillance ultrasonography detected a suspicious lesion involving the thyroid isthmus and left lobe. FNA was interpreted as Bethesda II (benign), but metastatic ccRCC was subsequently confirmed after total thyroidectomy. Histopathology showed focal vascular and capsular invasion. Tumor reached the margin of the main thyroid specimen, whereas separately submitted perithyroidal soft tissue had tumor-free margins, resulting in a final R0 resection. The tumor was positive for CK8/18, PAX8, EMA, vimentin, and CD10 and negative for TTF-1, thyroglobulin, calcitonin, and CD5. Postoperative 18F-FDG PET/CT showed no additional metastatic disease. Conclusions: Benign thyroid cytology should be interpreted cautiously in patients with previous ccRCC when clinical or imaging findings remain suspicious. Diagnosis requires integration of oncological history, imaging, histopathology, and immunohistochemistry. Surgical resection may provide local disease control in selected patients, with surveillance.
SN  - 2571-841X
ER  -