The role of stem cells in the pharmacological assessment of nanoparticles
- 1Department of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Qassim, 51452, Saudi Arabia; Corresponding author.
- 2College of Pharmacy, Qassim University, Qassim, 51452, Saudi Arabia
Abstract
Stem cells aid in the pharmacological assessment of nanoparticles by serving as a human-relevant, dynamic, and scalable model. Their integration into nanoparticle research enhances toxicity screening and therapeutic optimization by evaluating absorption, distribution, metabolism, excretion and toxicity (ADMET) parameters across models ranging from simple in vitro cultures to complex organoids. They provide insights into how nanoparticles interact with biological systems, guiding the rational design of safer, more effective nanomedicines. Conventional in vitro and animal models often fall short in recapitulating human-specific responses, as they cannot fully capture the complex interactions between nanoparticles and biological systems. This limitation significantly reduces the predictive accuracy of toxicity and efficacy assessments. In contrast, stem cell-based models offer a transformative platform by providing physiologically relevant, patient-specific and organotypic systems which help overcome critical challenges such as species differences, limited cellular diversity, and ethical concerns associated with animal testing. This review examines the fundamentals of nanoparticle and stem cell interactions, ADMET profiling, and the immunomodulatory properties of nanoparticles, all of which are pivotal for comprehensive pharmacological assessment. The key challenges such as standardization, long-term safety, and regulatory compliance that hinder clinical translation are also discussed.
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BibTeX
@article{alnasser2026role,
title = {{The role of stem cells in the pharmacological assessment of nanoparticles}},
author = {Sulaiman Mohammed Alnasser and Abdulaziz Khaled Aldoaiji and Rakan Abdulrahman Alharbi and Hussain Qassem Alhajjoj and Waleed Talal Aldebassi and Abdulrahman Ahmed Almaiman and Abdulelah Hussain Almutairi},
journal = {Journal of Pharmaceutical Analysis},
year = {2026},
month = sep,
doi = {10.1016/j.jpha.2026.101547},
url = {https://doi.org/10.1016/j.jpha.2026.101547},
note = {CC BY},
}
RIS
TY - JOUR
TI - The role of stem cells in the pharmacological assessment of nanoparticles
AU - Sulaiman Mohammed Alnasser
AU - Abdulaziz Khaled Aldoaiji
AU - Rakan Abdulrahman Alharbi
AU - Hussain Qassem Alhajjoj
AU - Waleed Talal Aldebassi
AU - Abdulrahman Ahmed Almaiman
AU - Abdulelah Hussain Almutairi
PY - 2026
DA - 2026/09/01
JO - Journal of Pharmaceutical Analysis
DO - 10.1016/j.jpha.2026.101547
UR - https://doi.org/10.1016/j.jpha.2026.101547
AB - Stem cells aid in the pharmacological assessment of nanoparticles by serving as a human-relevant, dynamic, and scalable model. Their integration into nanoparticle research enhances toxicity screening and therapeutic optimization by evaluating absorption, distribution, metabolism, excretion and toxicity (ADMET) parameters across models ranging from simple in vitro cultures to complex organoids. They provide insights into how nanoparticles interact with biological systems, guiding the rational design of safer, more effective nanomedicines. Conventional in vitro and animal models often fall short in recapitulating human-specific responses, as they cannot fully capture the complex interactions between nanoparticles and biological systems. This limitation significantly reduces the predictive accuracy of toxicity and efficacy assessments. In contrast, stem cell-based models offer a transformative platform by providing physiologically relevant, patient-specific and organotypic systems which help overcome critical challenges such as species differences, limited cellular diversity, and ethical concerns associated with animal testing. This review examines the fundamentals of nanoparticle and stem cell interactions, ADMET profiling, and the immunomodulatory properties of nanoparticles, all of which are pivotal for comprehensive pharmacological assessment. The key challenges such as standardization, long-term safety, and regulatory compliance that hinder clinical translation are also discussed.
SN - 2095-1779
SN - 2214-0883
ER -