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PreprintarXiv licencearXiv

Nanoscale NMR of DNA-Functionalized Diamond Using Individual NV Centers

  • Erika Janitz
  • Konstantin Herb
  • Laura A. Völker
  • Christian L. Degen
  • John M. Abendroth
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Abstract

Nuclear magnetic resonance (NMR) spectroscopy is a powerful probe of molecular structure and dynamics but typically requires large spin ensembles. Here, we demonstrate nanoscale NMR detection of fluorinated DNA using individual near-surface nitrogen-vacancy (NV) centers in diamond nanopillar waveguides under ambient conditions. We covalently tether 19F-labeled oligonucleotides to mixed nitrogen- and oxygen-terminated surfaces, localizing target spins within the nanoscale sensing volume. Probabilistic spin simulations suggest that the measured signals are consistent with those expected from a few molecules and depend strongly on NV-molecule separation, configuration, and local surface heterogeneity. These results establish a framework for NMR of surface-tethered biomolecules and identify key challenges for single-molecule structural elucidation.

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Cite

BibTeXRIS
BibTeX
@misc{janitz2026nanoscale,
  title = {{Nanoscale NMR of DNA-Functionalized Diamond Using Individual NV Centers}},
  author = {Erika Janitz and Konstantin Herb and Laura A. Völker and Christian L. Degen and John M. Abendroth},
  howpublished = {arXiv},
  year = {2026},
  month = sep,
  doi = {10.48550/arxiv.2609.05570},
  eprint = {2609.05570},
  archivePrefix = {arXiv},
  url = {https://arxiv.org/abs/2609.05570},
}
RIS
TY  - UNPB
TI  - Nanoscale NMR of DNA-Functionalized Diamond Using Individual NV Centers
AU  - Erika Janitz
AU  - Konstantin Herb
AU  - Laura A. Völker
AU  - Christian L. Degen
AU  - John M. Abendroth
PY  - 2026
DA  - 2026/09/04
PB  - arXiv
DO  - 10.48550/arxiv.2609.05570
UR  - https://arxiv.org/abs/2609.05570
AB  - Nuclear magnetic resonance (NMR) spectroscopy is a powerful probe of molecular structure and dynamics but typically requires large spin ensembles. Here, we demonstrate nanoscale NMR detection of fluorinated DNA using individual near-surface nitrogen-vacancy (NV) centers in diamond nanopillar waveguides under ambient conditions. We covalently tether ^19F-labeled oligonucleotides to mixed nitrogen- and oxygen-terminated surfaces, localizing target spins within the nanoscale sensing volume. Probabilistic spin simulations suggest that the measured signals are consistent with those expected from a few molecules and depend strongly on NV-molecule separation, configuration, and local surface heterogeneity. These results establish a framework for NMR of surface-tethered biomolecules and identify key challenges for single-molecule structural elucidation.
ER  -