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Peer-reviewedCC BY-NC 4.0Science Advances

A biofilm-derived peptide as an underwater adhesive

  • Xin Huang1,2
  • Ewelina D. Liszczyk1,3
  • Ramesh Prasad4
  • Megan E. Mitchell5,6
  • Zhijie Wang2
  • Yuchu Liu1
  • Sarvagya Saluja1
  • Mingyu Wang3
  • Rebekah A. Jackson2
  • Peter Dahl7,8
  • Roberto Andresen Eguiluz9
  • Nikhil Malvankar7,8
4 more authors
  • Elsa C. Y. Yan2
  • Rich Olson3
  • Huan-Xiang Zhou4,10
  • Jing Yan1,11
11 affiliations
  1. 1Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06511, USA.
  2. 2Department of Chemistry, Yale University, New Haven, CT 06520, USA.
  3. 3Department of Molecular Biology and Biochemistry, Molecular Biophysics Program, Wesleyan University, Middletown, CT 06459, USA.
  4. 4Department of Chemistry, University of Illinois Chicago, Chicago, IL 60607, USA.
  5. 5National Institute of Standards and Technology, Gaithersburg, MD 20899, USA.
  6. 6A. James Clark School of Engineering, University of Maryland, College Park, MD 20742, USA.
  7. 7Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511, USA.
  8. 8Microbial Sciences Institute, Yale University, West Haven, CT 06516, USA.
  9. 9Department of Chemical and Materials Engineering, University of California Merced, Merced, CA 95344, USA.
  10. 10Department of Physics, University of Illinois Chicago, Chicago, IL 60607, USA.
  11. 11Quantitative Biology Institute, Yale University, New Haven, CT 06511, USA.
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Abstract

Wet adhesives that perform under water have broad applications in industrial and biomedical settings. To date, molecular designs for underwater adhesives have largely been inspired by marine animals including mussels and barnacles. Here, we propose bacterial biofilms as an alternative source of inspiration for underwater adhesives. Specifically, we demonstrate the application potential of a peptide derived from biofilms formed by the notorious pathogen Vibrio cholerae. We characterize the ability of this biofilm-derived peptide to adsorb onto various surfaces and to glue wet surfaces by using a combination of confocal microscopy, molecular dynamics simulations, atomic force microscopy, lap shear tests, and spectroscopic tools. We further show that the peptide can coaggregate with microspheres acting as an effective flocculant. Our results open new design possibilities for underwater adhesives inspired by natural biofilms.

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Cite

BibTeXRIS
BibTeX
@article{huang2026biofilmderived,
  title = {{A biofilm-derived peptide as an underwater adhesive}},
  author = {Xin Huang and Ewelina D. Liszczyk and Ramesh Prasad and Megan E. Mitchell and Zhijie Wang and Yuchu Liu and Sarvagya Saluja and Mingyu Wang and Rebekah A. Jackson and Peter Dahl and Roberto Andresen Eguiluz and Nikhil Malvankar and Elsa C. Y. Yan and Rich Olson and Huan-Xiang Zhou and Jing Yan},
  journal = {Science Advances},
  year = {2026},
  month = nov,
  doi = {10.1126/sciadv.aei1795},
  url = {https://www.science.org/doi/abs/10.1126/sciadv.aei1795},
  note = {CC BY-NC 4.0},
}
RIS
TY  - JOUR
TI  - A biofilm-derived peptide as an underwater adhesive
AU  - Xin Huang
AU  - Ewelina D. Liszczyk
AU  - Ramesh Prasad
AU  - Megan E. Mitchell
AU  - Zhijie Wang
AU  - Yuchu Liu
AU  - Sarvagya Saluja
AU  - Mingyu Wang
AU  - Rebekah A. Jackson
AU  - Peter Dahl
AU  - Roberto Andresen Eguiluz
AU  - Nikhil Malvankar
AU  - Elsa C. Y. Yan
AU  - Rich Olson
AU  - Huan-Xiang Zhou
AU  - Jing Yan
PY  - 2026
DA  - 2026/11/04
JO  - Science Advances
DO  - 10.1126/sciadv.aei1795
UR  - https://www.science.org/doi/abs/10.1126/sciadv.aei1795
AB  - Wet adhesives that perform under water have broad applications in industrial and biomedical settings. To date, molecular designs for underwater adhesives have largely been inspired by marine animals including mussels and barnacles. Here, we propose bacterial biofilms as an alternative source of inspiration for underwater adhesives. Specifically, we demonstrate the application potential of a peptide derived from biofilms formed by the notorious pathogen Vibrio cholerae. We characterize the ability of this biofilm-derived peptide to adsorb onto various surfaces and to glue wet surfaces by using a combination of confocal microscopy, molecular dynamics simulations, atomic force microscopy, lap shear tests, and spectroscopic tools. We further show that the peptide can coaggregate with microspheres acting as an effective flocculant. Our results open new design possibilities for underwater adhesives inspired by natural biofilms.
SN  - 2375-2548
ER  -