Annexin A6 Interacts with Newcastle Disease Virus Matrix Protein and Is Associated with Reduced Viral Replication in DF-1 Cells.
4 affiliations
- 1School of Food and Biology Engineering, Xuzhou University of Technology, Xuzhou 221000, China.
- 2Animal Infectious Disease Laboratory, College of Veterinary Medicine, Yangzhou University, Yangzhou 225012, China.
- 3Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonosis, Yangzhou University, Yangzhou 225012, China.
- 4Jiangsu Key Laboratory of Zoonosis, Yangzhou University, Yangzhou 225012, China.
Abstract
Newcastle disease virus (NDV) incurs substantial economic losses within the global poultry industry. The matrix (M) protein of NDV is integral to viral replication. In this study, we examined the interaction between the NDV M protein and annexin A6 (AnxA6) in DF-1 cells. Our findings revealed that AnxA6 associates with the C-terminus of the NDV M protein, predominantly within the cytoplasm. Functional analyses indicated that the knockdown of AnxA6 expression significantly enhanced NDV replication, whereas the overexpression of AnxA6 inhibited viral replication. Taken together, these findings suggest that AnxA6 may function as a negative regulator of NDV replication in this cell culture model, potentially through its interaction with the M protein. This study offers new insights into the intricate relationship between viral proteins and host factors in NDV infection and suggests that AnxA6 may serve as a potential target for further investigation. Further research is necessary to elucidate the detailed mechanisms governing the AnxA6-M protein interaction.
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BibTeX
@article{xu2026annexin,
title = {{Annexin A6 Interacts with Newcastle Disease Virus Matrix Protein and Is Associated with Reduced Viral Replication in DF-1 Cells.}},
author = {Haixu Xu and Yu Chen and Shunlin Hu and Xiufan Liu},
journal = {Viruses},
year = {2026},
month = oct,
doi = {10.3390/v18101164},
url = {https://europepmc.org/article/MED/42944083},
note = {CC BY},
}
RIS
TY - JOUR
TI - Annexin A6 Interacts with Newcastle Disease Virus Matrix Protein and Is Associated with Reduced Viral Replication in DF-1 Cells.
AU - Haixu Xu
AU - Yu Chen
AU - Shunlin Hu
AU - Xiufan Liu
PY - 2026
DA - 2026/10/20
JO - Viruses
DO - 10.3390/v18101164
UR - https://europepmc.org/article/MED/42944083
AB - Newcastle disease virus (NDV) incurs substantial economic losses within the global poultry industry. The matrix (M) protein of NDV is integral to viral replication. In this study, we examined the interaction between the NDV M protein and annexin A6 (AnxA6) in DF-1 cells. Our findings revealed that AnxA6 associates with the C-terminus of the NDV M protein, predominantly within the cytoplasm. Functional analyses indicated that the knockdown of AnxA6 expression significantly enhanced NDV replication, whereas the overexpression of AnxA6 inhibited viral replication. Taken together, these findings suggest that AnxA6 may function as a negative regulator of NDV replication in this cell culture model, potentially through its interaction with the M protein. This study offers new insights into the intricate relationship between viral proteins and host factors in NDV infection and suggests that AnxA6 may serve as a potential target for further investigation. Further research is necessary to elucidate the detailed mechanisms governing the AnxA6-M protein interaction.
SN - 1999-4915
ER -