Impact of left ventricular reshaping on postinfarction functional mitral regurgitation in a chronic swine model of advanced heart failure.
4 affiliations
- 1Center for Regenerative Medicine, Research Institute at Nationwide Children's Hospital, Columbus, Ohio.
- 2Division of Plastic Surgery, Department of Surgery, McMaster University, Hamilton, Ontario, Canada.
- 3Lee Moffitt Cancer Center & Research Institute, Comparative Medicine Core Facility, Tampa, Fla.
- 4Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio.
Abstract
Objective
The study objective was to evaluate the efficacy and feasibility of left ventricular reshaping in a swine model of late-stage ischemic heart failure with marked left ventricular dilation and functional mitral regurgitation.Methods
A chronic heart failure model with ischemic mitral regurgitation was established in 8 Yorkshire swine via percutaneous injection of 100% ethanol into the left circumflex artery. The left ventricular reshaping device was implanted transapically at 6 months postinfarction and evaluated with echocardiography and pressure-volume loop analysis. The final efficacy analysis included 7 animals.Results
The device was successfully implanted and significantly reduced mitral regurgitation (regurgitant volume: 43.29 ± 14.47 mL vs 9.90 ± 5.12 mL, P = .0026). Posterior excursion angle (22.71 ± 6.92° vs 39.14 ± 7.29°, P = .0042) and coaptation length (2.72 ± 0.44 mm vs 4.42 ± 0.76 mm, P = .0033) increased significantly. Left ventricular volume significantly decreased after reshaping (indexed end-diastolic volume: 140.30 ± 28.28 mL/m² vs 84.68 ± 18.51 mL/m², P = .0019; indexed end-systolic volume: 91.54 ± 24.01 mL/m² vs 48.23 ± 16.25 mL/m², P = .0003). Ejection fraction significantly increased (33.71% ± 3.30% vs 43.43% ± 7.12%, P = .0046), whereas load-independent indices of systolic function and measures of diastolic function did not change significantly.Conclusions
Transapical left ventricular reshaping demonstrated acute efficacy and feasibility at 6 months postinfarction in advanced heart failure by reducing left ventricular volume and mitral regurgitation.
Related
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- Challenging the guidelines: longitudinal trends in left ventricular diameter and function in severe aortic regurgitation
BibTeX
@article{nakamae2026impact,
title = {{Impact of left ventricular reshaping on postinfarction functional mitral regurgitation in a chronic swine model of advanced heart failure.}},
author = {Kosuke Nakamae and Chihiro Miyagi and Junya Matsuda and Syed Faizullah Hussaini and Tatsuya Watanabe and Satoshi Yuhara and Adrienne Morrison and Kirsten Nelson and Filip Konecny and Daisuke Onohara},
journal = {JTCVS open},
year = {2026},
month = aug,
doi = {10.1016/j.xjon.2026.102080},
url = {https://europepmc.org/article/MED/42948581},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Impact of left ventricular reshaping on postinfarction functional mitral regurgitation in a chronic swine model of advanced heart failure.
AU - Kosuke Nakamae
AU - Chihiro Miyagi
AU - Junya Matsuda
AU - Syed Faizullah Hussaini
AU - Tatsuya Watanabe
AU - Satoshi Yuhara
AU - Adrienne Morrison
AU - Kirsten Nelson
AU - Filip Konecny
AU - Daisuke Onohara
PY - 2026
DA - 2026/08/23
JO - JTCVS open
DO - 10.1016/j.xjon.2026.102080
UR - https://europepmc.org/article/MED/42948581
AB - Objective The study objective was to evaluate the efficacy and feasibility of left ventricular reshaping in a swine model of late-stage ischemic heart failure with marked left ventricular dilation and functional mitral regurgitation.Methods A chronic heart failure model with ischemic mitral regurgitation was established in 8 Yorkshire swine via percutaneous injection of 100% ethanol into the left circumflex artery. The left ventricular reshaping device was implanted transapically at 6 months postinfarction and evaluated with echocardiography and pressure-volume loop analysis. The final efficacy analysis included 7 animals.Results The device was successfully implanted and significantly reduced mitral regurgitation (regurgitant volume: 43.29 ± 14.47 mL vs 9.90 ± 5.12 mL, P = .0026). Posterior excursion angle (22.71 ± 6.92° vs 39.14 ± 7.29°, P = .0042) and coaptation length (2.72 ± 0.44 mm vs 4.42 ± 0.76 mm, P = .0033) increased significantly. Left ventricular volume significantly decreased after reshaping (indexed end-diastolic volume: 140.30 ± 28.28 mL/m² vs 84.68 ± 18.51 mL/m², P = .0019; indexed end-systolic volume: 91.54 ± 24.01 mL/m² vs 48.23 ± 16.25 mL/m², P = .0003). Ejection fraction significantly increased (33.71% ± 3.30% vs 43.43% ± 7.12%, P = .0046), whereas load-independent indices of systolic function and measures of diastolic function did not change significantly.Conclusions Transapical left ventricular reshaping demonstrated acute efficacy and feasibility at 6 months postinfarction in advanced heart failure by reducing left ventricular volume and mitral regurgitation.
SN - 2666-2736
ER -