Immunomodulatory effects of high versus low intensity diode laser as adjunct to non-surgical periodontal therapy in periodontitis.
6 affiliations
- 1Oral Medicine and Periodontology Department, College of Dentistry, University of Sciences and Technology, Sana'a, Yemen. [email protected].
- 2Department of Biological and Preventive Sciences, College of Dentistry, University of Sciences and Technology, Sana'a, Yemen. [email protected].
- 3Oral Medicine and Periodontology Department, College of Dentistry, University of Sciences and Technology, Sana'a, Yemen.
- 4Department of Periodontology, Faculty of Dentistry, Thamar University, Dhamar, Yemen.
- 5Department of Dentistry, Faculty of Medical Sciences, Civilization University, Sana'a, Yemen.
- 6Department of Restorative Dental Science, College of Dentistry, University of Ha'il, Ha'il, Kingdom of Saudi Arabia.
Abstract
Objective
Periodontitis is characterized by a dysregulated inflammatory response mediated by proinflammatory cytokines. This study aimed to compare the immunomodulatory effects of high-intensity (DLT-H) versus low-intensity (DLT-L) diode laser therapy as adjuncts to conventional scaling and root planning (SRP) in patients with periodontitis.Results
Twenty-seven participants contributing 81 non-adjacent periodontal sites were randomly assigned into three treatment groups: SRP alone, SRP + DLT-H, and SRP + DLT-L. Gingival crevicular fluid (GCF) was collected at baseline, 1 month, and 3 months post-treatment to quantify levels of IL-1β, IL-6, IL-8, and TNF-α. All treatment modalities led to significant reductions in pro-inflammatory cytokine levels over time (p < 0.01). DLT-H produced the most pronounced and sustained decreases, with early and long-term suppression significantly greater than both SRP alone and DLT-L. DLT-L yielded moderate yet consistent reductions across all cytokines, whereas SRP alone demonstrated limited and less durable immunomodulatory effects. Pairwise comparisons highlighted the superior efficacy of DLT-H in both early (baseline to 1 month) and late (1 to 3 months) intervals, particularly for IL-6 and TNF-α. These findings indicate that high-intensity diode laser therapy provides superior and modulatory benefits and may enhance the outcomes of nonsurgical periodontal therapy.
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BibTeX
@article{alsharani2026immunomodulatory,
title = {{Immunomodulatory effects of high versus low intensity diode laser as adjunct to non-surgical periodontal therapy in periodontitis.}},
author = {Amani A Al-Sharani and Wadhah A Al-Hajj and Ahmed A Madfa},
journal = {BMC research notes},
year = {2026},
month = jul,
doi = {10.1186/s13104-026-07955-8},
url = {https://europepmc.org/article/MED/42902332},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Immunomodulatory effects of high versus low intensity diode laser as adjunct to non-surgical periodontal therapy in periodontitis.
AU - Amani A Al-Sharani
AU - Wadhah A Al-Hajj
AU - Ahmed A Madfa
PY - 2026
DA - 2026/07/01
JO - BMC research notes
DO - 10.1186/s13104-026-07955-8
UR - https://europepmc.org/article/MED/42902332
AB - Objective Periodontitis is characterized by a dysregulated inflammatory response mediated by proinflammatory cytokines. This study aimed to compare the immunomodulatory effects of high-intensity (DLT-H) versus low-intensity (DLT-L) diode laser therapy as adjuncts to conventional scaling and root planning (SRP) in patients with periodontitis.Results Twenty-seven participants contributing 81 non-adjacent periodontal sites were randomly assigned into three treatment groups: SRP alone, SRP + DLT-H, and SRP + DLT-L. Gingival crevicular fluid (GCF) was collected at baseline, 1 month, and 3 months post-treatment to quantify levels of IL-1β, IL-6, IL-8, and TNF-α. All treatment modalities led to significant reductions in pro-inflammatory cytokine levels over time (p < 0.01). DLT-H produced the most pronounced and sustained decreases, with early and long-term suppression significantly greater than both SRP alone and DLT-L. DLT-L yielded moderate yet consistent reductions across all cytokines, whereas SRP alone demonstrated limited and less durable immunomodulatory effects. Pairwise comparisons highlighted the superior efficacy of DLT-H in both early (baseline to 1 month) and late (1 to 3 months) intervals, particularly for IL-6 and TNF-α. These findings indicate that high-intensity diode laser therapy provides superior and modulatory benefits and may enhance the outcomes of nonsurgical periodontal therapy.
SN - 1756-0500
ER -