Evaluation of the genotoxic potential of two rice herbicides, cyhalofop-butyl and quinclorac, in Drosophila melanogaster
Abstract
Cyhalofop-butyl, an aryloxyphenoxypropionate acetyl-CoA carboxylase (ACCase) inhibitor, and quinclorac, a quinolinecarboxylic acid herbicide with auxin-like activity, are commonly used in rice production. This study evaluated the genotoxic potential of the herbicides cyhalofop-butyl and quinclorac in the in vivo Drosophila melanogaster smart assay. Trans-heterozygous larvae obtained from crosses between the multiple wing hairs ( mwh ) and flare -3 ( flr ³ ) strains were exposed to four concentrations (1, 2, 5, and 10 ppm) of each herbicide. Both herbicides significantly increased clone frequencies compared with the negative control. Cyhalofop-butyl exhibited a concentration-related increase in total spot frequencies, whereas quinclorac consistently elevated clone frequencies across all tested concentrations without a clear dose-dependent pattern. To the best of our knowledge, this is the first report demonstrating the genotoxic potential of cyhalofop-butyl. These findings emphasize the need for careful use of herbicides in rice production and support further investigation of alternative products with lower or no genotoxic potential.
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BibTeX
@article{kocaoglucenkci2026evaluation,
title = {{Evaluation of the genotoxic potential of two rice herbicides, cyhalofop-butyl and quinclorac, in Drosophila melanogaster}},
author = {Serap Kocaoğlu-Cenkci},
journal = {PeerJ},
year = {2026},
month = oct,
doi = {10.7717/peerj.21747},
url = {https://peerj.com/articles/21747},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Evaluation of the genotoxic potential of two rice herbicides, cyhalofop-butyl and quinclorac, in Drosophila melanogaster
AU - Serap Kocaoğlu-Cenkci
PY - 2026
DA - 2026/10/05
JO - PeerJ
DO - 10.7717/peerj.21747
UR - https://peerj.com/articles/21747
AB - Cyhalofop-butyl, an aryloxyphenoxypropionate acetyl-CoA carboxylase (ACCase) inhibitor, and quinclorac, a quinolinecarboxylic acid herbicide with auxin-like activity, are commonly used in rice production. This study evaluated the genotoxic potential of the herbicides cyhalofop-butyl and quinclorac in the in vivo Drosophila melanogaster smart assay. Trans-heterozygous larvae obtained from crosses between the multiple wing hairs ( mwh ) and flare -3 ( flr ³ ) strains were exposed to four concentrations (1, 2, 5, and 10 ppm) of each herbicide. Both herbicides significantly increased clone frequencies compared with the negative control. Cyhalofop-butyl exhibited a concentration-related increase in total spot frequencies, whereas quinclorac consistently elevated clone frequencies across all tested concentrations without a clear dose-dependent pattern. To the best of our knowledge, this is the first report demonstrating the genotoxic potential of cyhalofop-butyl. These findings emphasize the need for careful use of herbicides in rice production and support further investigation of alternative products with lower or no genotoxic potential.
SN - 2167-8359
ER -