Isotopic Fractionation and Neural Synchronization — An Exploratory Hypothesis
Abstract
High-order neural networks evolved from unicellular progenitors that used Quorum Sensing (QS) for collective coordination. This note examines whether metabolic isotopic fractionation could supply a flow-robust contribution to synaptic timing and network synchrony in neural tissue. We review the relevant kinetic isotope effects, place them in the context of the astrocyte-neuron lactate shuttle, and write a phenomenological coupling between local isotopic enrichment and an effective phase-mismatch variable. A brief order-of-magnitude discussion compares expected isotopic shifts with thermal and synaptic noise. The fine-structure-related coherence window used in earlier G-MaTT notes is treated as an optional importation rather than a derived neural threshold. Concrete experimental tests are proposed. The work is an organising hypothesis, not a quantitative theory of cortical gamma oscillations.
Related
- The Isotopic Metronome — Isotopic Fractionation, Developmental Timing and Speciation as an Organising Hypothesis in Phase Torsional Biology
- Structural control over equilibrium silicon and oxygen isotopic fractionation: A first-principles density-functional theory study
- Topological Oncology — Isotopic Fractionation as a Possible Wave-Impedance Shift and Phase-Decoherence Organiser in Malignant Networks
- First-principles calculation of H/D isotopic fractionation between hydrous minerals and water
- Isotopic fractionation during ice growth by riming and its effect on the d -excess of precipitation
BibTeX
@misc{yeo2026isotopic,
title = {{Isotopic Fractionation and Neural Synchronization — An Exploratory Hypothesis}},
author = {Soon Hee@Bungsuh Yeo},
howpublished = {Zenodo},
year = {2026},
month = oct,
doi = {10.5281/zenodo.23641608},
url = {https://zenodo.org/records/23641608},
note = {CC BY 4.0},
}
RIS
TY - UNPB
TI - Isotopic Fractionation and Neural Synchronization — An Exploratory Hypothesis
AU - Soon Hee@Bungsuh Yeo
PY - 2026
DA - 2026/10/25
PB - Zenodo
DO - 10.5281/zenodo.23641608
UR - https://zenodo.org/records/23641608
AB - High-order neural networks evolved from unicellular progenitors that used Quorum Sensing (QS) for collective coordination. This note examines whether metabolic isotopic fractionation could supply a flow-robust contribution to synaptic timing and network synchrony in neural tissue. We review the relevant kinetic isotope effects, place them in the context of the astrocyte-neuron lactate shuttle, and write a phenomenological coupling between local isotopic enrichment and an effective phase-mismatch variable. A brief order-of-magnitude discussion compares expected isotopic shifts with thermal and synaptic noise. The fine-structure-related coherence window used in earlier G-MaTT notes is treated as an optional importation rather than a derived neural threshold. Concrete experimental tests are proposed. The work is an organising hypothesis, not a quantitative theory of cortical gamma oscillations.
ER -