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Peer-reviewedLicence not statedNature Genetics

H3K27me3 spreading organizes canonical PRC1 chromatin architecture to regulate developmental programs

  • Brian Krug1,2,3,4,5,6,7
  • Bo Hu8,2,9,10,11,5,12,13
  • Haifeng Chen2,9,5,14,13
  • Claudia Negrón-Lomas2,11,5
  • Xiao Chen1,15,4,16,17
  • Ahmed El Mouatani2,4,16
  • Kristjan H. Gretarsson1,18
  • Adam Ptack2,11,5,19
  • Shriya Deshmukh20,11,5
  • Nisha Kabir2,21,18
  • Wajih Jawhar20,11,5
  • Augusto Faria Andrade22,2,23,24,25,26,27
25 more authors
  • Elias Joseph Jabbour20,11,5
  • Ashot S. Harutyunyan2,28
  • Xinrui Wang20,28
  • Robert Taylor2,4
  • John J. Y. Lee29,30,31,32,33,34,35
  • Maud Hulswit2,36
  • Damien Faury37,38,39
  • Caterina Russo37,40
  • Xinjing Xu1
  • Jiahan Yang1,12,13
  • Audrey Baguette21
  • Nathan A. Dahl
  • Alexander Gregory Weil
  • Benjamin Ellezam
  • Rola Dali9,32,33,34,35
  • Mathieu Blanchette25,26,27
  • Khadija Wilson11,5,19
  • Benjamin Aaron Garcia11,5,12,13
  • Rajesh Kumar Soni11,5,28,18
  • Marco Gallo22,23,4,16
  • Michael D. Taylor22,23,31
  • Claudia L. Kleinman2,21
  • Jacek Majewski2,9
  • Nada Jabado
  • Chao Lü1
40 affiliations
  1. 1Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY, USA
  2. 2Department of Human Genetics, McGill University, Montreal, Quebec, Canada
  3. 3Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY 0032, USA, 28
  4. 4Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY 1003, USA
  5. 5Department of Human Genetics, McGill University, Montreal, QC H3A B, Canada
  6. 6Department of Human Genetics, McGill University, Montreal, QC H3A B, Canada, 2
  7. 7These authors contributed equally
  8. 8Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto, Japan
  9. 9McGill University Genome Centre, Montreal, Quebec, Canada
  10. 10Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan
  11. 11Department of Human Genetics, McGill University, Montreal, QC H3A 1B1, Canada
  12. 12McGill University Genome Centre, Montreal, QC H3A 0G1, Canada
  13. 13McGill University Genome Centre, Montreal, QC HA 0G1, Canada
  14. 14Department of Human Genetics, McGill University, Montreal, QC HA 1B1, Canada
  15. 15Marine College, Shandong University, Weihai, China
  16. 16Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY 10032, USA
  17. 17Marine College, Shandong University, Weihai, 264209, China
  18. 18Division of Experimental Medicine, Department of Medicine, McGill University, Montreal, QC H4A 3J1, Canada
  19. 19The Lady Davis Institute, Jewish General Hospital, Montreal, QC H3T 1E2, Canada
  20. 20Division of Experimental Medicine, Department of Medicine, McGill University, Montreal, Quebec, Canada
  21. 21The Lady Davis Institute, Jewish General Hospital, Montreal, Quebec, Canada
  22. 22Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
  23. 23Department of Molecular Biology and Biochemistry, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
  24. 24Department of Laboratory Medicine
  25. 25Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G 1L7, Canada
  26. 26Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada
  27. 27The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada
  28. 28Department of Pediatrics, McGill University, The Research Institute of the McGill University Health Center, Montreal, QC H4A 3J1, Canada
  29. 29Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
  30. 30Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada
  31. 31The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, Ontario, Canada
  32. 32Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 1N4, Canada
  33. 33Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 1N4, Canada
  34. 34Department
  35. 35Department of Molecular Biology and Biochemistry, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 1N4, Canada
  36. 36Quantitative Life Sciences, McGill University, Montreal, QC H3A 1B9, Canada
  37. 37Department of Pediatrics, McGill University, The Research Institute of the McGill University Health Center, Montreal, Quebec, Canada
  38. 38Morgan Adams Foundation Pediatric Brain Tumor Research Program, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO 80045, USA
  39. 39Pediatric Neuro-Oncology, Center for Cancer and Blood Disorders, Children's Hospital Colorado, Aurora, CO 80045, USA
  40. 40Department of Pediatric Neurosurgery, Centre Hospitalier Universitaire Sainte-Justine, Universite de Montreal, Montreal, QC H3T 1C5, Canada
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Cite

BibTeXRIS
BibTeX
@article{krug2026h3k27me3,
  title = {{H3K27me3 spreading organizes canonical PRC1 chromatin architecture to regulate developmental programs}},
  author = {Brian Krug and Bo Hu and Haifeng Chen and Claudia Negrón-Lomas and Xiao Chen and Ahmed El Mouatani and Kristjan H. Gretarsson and Adam Ptack and Shriya Deshmukh and Nisha Kabir and Wajih Jawhar and Augusto Faria Andrade and Elias Joseph Jabbour and Ashot S. Harutyunyan and Xinrui Wang and Robert Taylor and John J. Y. Lee and Maud Hulswit and Damien Faury and Caterina Russo and Xinjing Xu and Jiahan Yang and Audrey Baguette and Nathan A. Dahl and Alexander Gregory Weil and Benjamin Ellezam and Rola Dali and Mathieu Blanchette and Khadija Wilson and Benjamin Aaron Garcia and Rajesh Kumar Soni and Marco Gallo and Michael D. Taylor and Claudia L. Kleinman and Jacek Majewski and Nada Jabado and Chao Lü},
  journal = {Nature Genetics},
  year = {2026},
  month = may,
  doi = {10.1038/s41588-026-02586-y},
  url = {https://doi.org/10.1101/2023.11.28.567931},
}
RIS
TY  - JOUR
TI  - H3K27me3 spreading organizes canonical PRC1 chromatin architecture to regulate developmental programs
AU  - Brian Krug
AU  - Bo Hu
AU  - Haifeng Chen
AU  - Claudia Negrón-Lomas
AU  - Xiao Chen
AU  - Ahmed El Mouatani
AU  - Kristjan H. Gretarsson
AU  - Adam Ptack
AU  - Shriya Deshmukh
AU  - Nisha Kabir
AU  - Wajih Jawhar
AU  - Augusto Faria Andrade
AU  - Elias Joseph Jabbour
AU  - Ashot S. Harutyunyan
AU  - Xinrui Wang
AU  - Robert Taylor
AU  - John J. Y. Lee
AU  - Maud Hulswit
AU  - Damien Faury
AU  - Caterina Russo
AU  - Xinjing Xu
AU  - Jiahan Yang
AU  - Audrey Baguette
AU  - Nathan A. Dahl
AU  - Alexander Gregory Weil
AU  - Benjamin Ellezam
AU  - Rola Dali
AU  - Mathieu Blanchette
AU  - Khadija Wilson
AU  - Benjamin Aaron Garcia
AU  - Rajesh Kumar Soni
AU  - Marco Gallo
AU  - Michael D. Taylor
AU  - Claudia L. Kleinman
AU  - Jacek Majewski
AU  - Nada Jabado
AU  - Chao Lü
PY  - 2026
DA  - 2026/05/18
JO  - Nature Genetics
DO  - 10.1038/s41588-026-02586-y
UR  - https://doi.org/10.1101/2023.11.28.567931
SN  - 1061-4036
SN  - 1546-1718
ER  -