Targeted physical therapy for gouty arthritis: a first-principles frequency-screening study.
- 1Shandong Provincial Key Laboratory of Nuclear Science, Nuclear Energy Technology and Comprehensive Utilization, Weihai Frontier Innovation Institute of Nuclear Technology, Shandong University, Weihai, China.
- 2School of Space Science and Technology, Shandong University, Weihai, China.
- 3SDU-ANU Joint Science College, Shandong University, Weihai, China.
Abstract
Introduction
Gouty arthritis is caused by the deposition of monosodium urate monohydrate (MSUM) crystals in joints. Current drug therapies are often limited by side effects, and invasive procedures carry associated risks. This study aims to provide a theoretical basis for local physical treatment of gout by identifying specific mid-infrared frequencies for irradiating MSUM crystals via photon-phonon resonant absorption.Methods
The vibrational spectra of crystalline MSUM were simulated using first-principles density functional theory. The infrared and Raman peaks were mapped to their corresponding vibrational modes, and relative infrared activities were analyzed. The infrared spectrum of an anhydrous monosodium urate model (anhydrous MSU) was also calculated.Results
Analysis of the vibrational spectra revealed infrared characteristic peaks at 1637 and 1696 cm⁻¹ for MSUM and at 1627 and 1705 cm⁻¹ for anhydrous MSU. This finding provides the theoretical foundation for scanning 1627-1705 cm⁻¹ (48.78-51.11 THz) to resonantly excite the crystals.Discussion
The irradiation of MSUM crystals with a mid-infrared laser near 50 THz is proposed for initial frequency-scanning experiments. A optical fiber placed near deeper deposits could shorten the distance traveled through tissue. However, experimental validation is required to determine suitable irradiation conditions and assess safety and efficacy.
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BibTeX
@article{xia2026targeted,
title = {{Targeted physical therapy for gouty arthritis: a first-principles frequency-screening study.}},
author = {Yuqi Xia and Yifan Guan and Peilin Li and Yitong Wang and Yawen Li and Mingyan Xie and Zhe Wang and Kai Li and Peng Zhang},
journal = {Frontiers in physiology},
year = {2026},
month = oct,
doi = {10.3389/fphys.2026.1868909},
url = {https://europepmc.org/article/MED/42903097},
note = {CC BY},
}
RIS
TY - JOUR
TI - Targeted physical therapy for gouty arthritis: a first-principles frequency-screening study.
AU - Yuqi Xia
AU - Yifan Guan
AU - Peilin Li
AU - Yitong Wang
AU - Yawen Li
AU - Mingyan Xie
AU - Zhe Wang
AU - Kai Li
AU - Peng Zhang
PY - 2026
DA - 2026/10/06
JO - Frontiers in physiology
DO - 10.3389/fphys.2026.1868909
UR - https://europepmc.org/article/MED/42903097
AB - Introduction Gouty arthritis is caused by the deposition of monosodium urate monohydrate (MSUM) crystals in joints. Current drug therapies are often limited by side effects, and invasive procedures carry associated risks. This study aims to provide a theoretical basis for local physical treatment of gout by identifying specific mid-infrared frequencies for irradiating MSUM crystals via photon-phonon resonant absorption.Methods The vibrational spectra of crystalline MSUM were simulated using first-principles density functional theory. The infrared and Raman peaks were mapped to their corresponding vibrational modes, and relative infrared activities were analyzed. The infrared spectrum of an anhydrous monosodium urate model (anhydrous MSU) was also calculated.Results Analysis of the vibrational spectra revealed infrared characteristic peaks at 1637 and 1696 cm⁻¹ for MSUM and at 1627 and 1705 cm⁻¹ for anhydrous MSU. This finding provides the theoretical foundation for scanning 1627-1705 cm⁻¹ (48.78-51.11 THz) to resonantly excite the crystals.Discussion The irradiation of MSUM crystals with a mid-infrared laser near 50 THz is proposed for initial frequency-scanning experiments. A optical fiber placed near deeper deposits could shorten the distance traveled through tissue. However, experimental validation is required to determine suitable irradiation conditions and assess safety and efficacy.
SN - 1664-042X
ER -