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Peer-reviewedCC BYFrontiers in Medicine

Waldenström macroglobulinemia presenting with lumbar vertebral fracture as the initial symptom: a rare case report and literature review

  • Li Xu1
  • Chen Shen1
  • Jian Mi1
  • Zihan Hu1
  • Qifeng Sheng1
  • Pengfei Zhu1
  • Zhuorun Song1
  • Feng Zhou1
  1. 1epartment of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou, China
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Abstract

Waldenström macroglobulinemia (WM) is a rare type of B-cell lymphoma characterized by lymphoplasmacytic infiltration in the bone marrow and elevated serum monoclonal immunoglobulin M (IgM). Pathological bone-destructive lesions are exceedingly uncommon in this disease. Cases of WM presenting initially with lumbar vertebral fractures have been sporadically reported in clinical practice. We also outline the features that distinguish WM-related fractures from those caused by multiple myeloma and skeletal metastases, and summarize 12 previously published cases identified by a systematic PubMed search.

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Cite

BibTeXRIS
BibTeX
@article{xu2026waldenström,
  title = {{Waldenström macroglobulinemia presenting with lumbar vertebral fracture as the initial symptom: a rare case report and literature review}},
  author = {Li Xu and Chen Shen and Jian Mi and Zihan Hu and Qifeng Sheng and Pengfei Zhu and Zhuorun Song and Feng Zhou},
  journal = {Frontiers in Medicine},
  year = {2026},
  month = oct,
  doi = {10.3389/fmed.2026.1947916},
  url = {https://doi.org/10.3389/fmed.2026.1947916},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Waldenström macroglobulinemia presenting with lumbar vertebral fracture as the initial symptom: a rare case report and literature review
AU  - Li Xu
AU  - Chen Shen
AU  - Jian Mi
AU  - Zihan Hu
AU  - Qifeng Sheng
AU  - Pengfei Zhu
AU  - Zhuorun Song
AU  - Feng Zhou
PY  - 2026
DA  - 2026/10/23
JO  - Frontiers in Medicine
DO  - 10.3389/fmed.2026.1947916
UR  - https://doi.org/10.3389/fmed.2026.1947916
AB  - Waldenström macroglobulinemia (WM) is a rare type of B-cell lymphoma characterized by lymphoplasmacytic infiltration in the bone marrow and elevated serum monoclonal immunoglobulin M (IgM). Pathological bone-destructive lesions are exceedingly uncommon in this disease. Cases of WM presenting initially with lumbar vertebral fractures have been sporadically reported in clinical practice. We also outline the features that distinguish WM-related fractures from those caused by multiple myeloma and skeletal metastases, and summarize 12 previously published cases identified by a systematic PubMed search.
SN  - 2296-858X
ER  -