Prognostic Value of Thromboelastography Parameters for Early Trauma-Induced Coagulopathy in Severely Injured Patients: A Retrospective Cohort Study.
- 1Department of Anaesthesiology and Intensive Care Medicine, Medical University of Graz, Graz, Austria.
Abstract
Background and importance
Early trauma-induced coagulopathy (eTIC) is a major contributor to hemorrhage-related mortality after severe trauma. Viscoelastic testing using thromboelastography (TEG) has been increasingly implemented in trauma resuscitation; however, its prognostic value compared with conventional coagulation testing remains uncertain.Objectives
We evaluated the ability of TEG parameters to detect eTIC, hypofibrinogenemia, and hyperfibrinolysis in severely injured trauma patients. In addition, we assessed their prognostic performance for transfusion requirements and mortality compared with conventional laboratory parameters.Design
Retrospective single-center cohort study.Settings and participants
Severely injured adult trauma patients admitted to the resuscitation room of a Level I trauma center, between January 2019 and October 2024 were screened.Outcome measures and analysis
Primary outcomes were detection of eTIC (INR > 1.2), severe coagulopathy (INR > 1.5), hypofibrinogenemia (< 200 mg/dL), and thrombocytopenia (< 100,000/μL). Secondary outcomes included the ability of coagulation parameters to predict the need for transfusion of ≥ 5 units of packed red blood cells within the first 24 h after admission and in-hospital mortality.Results
A total of 262 patients were included; median ISS was 29 (IQR 23-41), and in-hospital mortality was 22.8%. eTIC was present in 31.5% of patients. TEG parameters showed moderate discriminatory performance for coagulopathy detection. For eTIC, maximum amplitude achieved an AUC of 0.73, while R-time achieved an AUC of 0.65. Predictive performance improved for severe coagulopathy, with R-time reaching an AUC of 0.81. Hyperfibrinolysis (LY30 > 7%) was uncommon (6.9%). Conventional laboratory parameters, particularly INR, consistently outperformed TEG-derived parameters for prediction of transfusion requirements (AUC 0.85) and mortality (AUC 0.79).Conclusion
In severely injured trauma patients, conventional coagulation testing, particularly INR, demonstrated superior prognostic performance compared with individual TEG parameters. Viscoelastic testing may provide complementary information but did not replace standard laboratory testing for prediction of transfusion needs or mortality in this cohort.Trial registration
ClinicalTrials.gov identifier: NCT07186712.
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BibTeX
@article{honnef2026prognostic,
title = {{Prognostic Value of Thromboelastography Parameters for Early Trauma-Induced Coagulopathy in Severely Injured Patients: A Retrospective Cohort Study.}},
author = {Gabriel Honnef and Philipp Zoidl and Barbara Hallmann and Moritz Missmann and Michael Eichinger and Maximilian Niederer and Paul Zajic},
journal = {Academic emergency medicine : official journal of the Society for Academic Emergency Medicine},
year = {2026},
month = oct,
doi = {10.1111/acem.70423},
url = {https://europepmc.org/article/MED/42902959},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Prognostic Value of Thromboelastography Parameters for Early Trauma-Induced Coagulopathy in Severely Injured Patients: A Retrospective Cohort Study.
AU - Gabriel Honnef
AU - Philipp Zoidl
AU - Barbara Hallmann
AU - Moritz Missmann
AU - Michael Eichinger
AU - Maximilian Niederer
AU - Paul Zajic
PY - 2026
DA - 2026/10/01
JO - Academic emergency medicine : official journal of the Society for Academic Emergency Medicine
DO - 10.1111/acem.70423
UR - https://europepmc.org/article/MED/42902959
AB - Background and importance Early trauma-induced coagulopathy (eTIC) is a major contributor to hemorrhage-related mortality after severe trauma. Viscoelastic testing using thromboelastography (TEG) has been increasingly implemented in trauma resuscitation; however, its prognostic value compared with conventional coagulation testing remains uncertain.Objectives We evaluated the ability of TEG parameters to detect eTIC, hypofibrinogenemia, and hyperfibrinolysis in severely injured trauma patients. In addition, we assessed their prognostic performance for transfusion requirements and mortality compared with conventional laboratory parameters.Design Retrospective single-center cohort study.Settings and participants Severely injured adult trauma patients admitted to the resuscitation room of a Level I trauma center, between January 2019 and October 2024 were screened.Outcome measures and analysis Primary outcomes were detection of eTIC (INR > 1.2), severe coagulopathy (INR > 1.5), hypofibrinogenemia (< 200 mg/dL), and thrombocytopenia (< 100,000/μL). Secondary outcomes included the ability of coagulation parameters to predict the need for transfusion of ≥ 5 units of packed red blood cells within the first 24 h after admission and in-hospital mortality.Results A total of 262 patients were included; median ISS was 29 (IQR 23-41), and in-hospital mortality was 22.8%. eTIC was present in 31.5% of patients. TEG parameters showed moderate discriminatory performance for coagulopathy detection. For eTIC, maximum amplitude achieved an AUC of 0.73, while R-time achieved an AUC of 0.65. Predictive performance improved for severe coagulopathy, with R-time reaching an AUC of 0.81. Hyperfibrinolysis (LY30 > 7%) was uncommon (6.9%). Conventional laboratory parameters, particularly INR, consistently outperformed TEG-derived parameters for prediction of transfusion requirements (AUC 0.85) and mortality (AUC 0.79).Conclusion In severely injured trauma patients, conventional coagulation testing, particularly INR, demonstrated superior prognostic performance compared with individual TEG parameters. Viscoelastic testing may provide complementary information but did not replace standard laboratory testing for prediction of transfusion needs or mortality in this cohort.Trial registration ClinicalTrials.gov identifier: NCT07186712.
SN - 1069-6563
SN - 1553-2712
ER -