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Peer-reviewedCC BY 4.0Reviews in Cardiovascular Medicine

Exploration of the Pathogenesis and Treatment of Heart Failure

  • Bihai Wen1,2,3,4
  • Shasha Yang1,2,3,4
  • Huibo Wang1,2,3,4
4 affiliations
  1. 1Department of Cardiology, Affiliated Central People's Hospital, China Three Gorges University, 443003 Yichang, Hubei, China
  2. 2Department of Cardiology, Yichang Central People's Hospital, 443003 Yichang, Hubei, China
  3. 3Hubei Key Laboratory of Ischemic Cardiovascular Disease, Yichang Central People's Hospital, 443003 Yichang, Hubei, China
  4. 4Hubei Provincial Clinical Research Center for Ischemic Cardiovascular Disease, Yichang Central People's Hospital, 443003 Yichang, Hubei, China
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Abstract

Heart failure represents the terminal stage of various cardiac diseases; the global prevalence of heart failure has been steadily increasing and poses a significant public health burden. With ongoing advances in molecular biology, clinical epidemiology, and translational medicine, research on heart failure has progressed significantly. Thus, understanding of the pathogenesis of heart failure has expanded beyond traditional hemodynamic abnormalities to encompass multidimensional, interrelated mechanisms, including neurohumoral imbalance, myocardial remodeling (hypertrophy and fibrosis), energy metabolism disorders, epigenetic regulation, and gut microbiota dysbiosis. This review systematically summarizes recent key advances in elucidating heart failure pathogenesis and iterative updates to treatment strategies, drawing on fundamental and translational research in this field.

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Cite

BibTeXRIS
BibTeX
@article{wen2026exploration,
  title = {{Exploration of the Pathogenesis and Treatment of Heart Failure}},
  author = {Bihai Wen and Shasha Yang and Huibo Wang},
  journal = {Reviews in Cardiovascular Medicine},
  year = {2026},
  month = oct,
  doi = {10.31083/rcm52463},
  url = {https://doi.org/10.31083/rcm52463},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Exploration of the Pathogenesis and Treatment of Heart Failure
AU  - Bihai Wen
AU  - Shasha Yang
AU  - Huibo Wang
PY  - 2026
DA  - 2026/10/16
JO  - Reviews in Cardiovascular Medicine
DO  - 10.31083/rcm52463
UR  - https://doi.org/10.31083/rcm52463
AB  - Heart failure represents the terminal stage of various cardiac diseases; the global prevalence of heart failure has been steadily increasing and poses a significant public health burden. With ongoing advances in molecular biology, clinical epidemiology, and translational medicine, research on heart failure has progressed significantly. Thus, understanding of the pathogenesis of heart failure has expanded beyond traditional hemodynamic abnormalities to encompass multidimensional, interrelated mechanisms, including neurohumoral imbalance, myocardial remodeling (hypertrophy and fibrosis), energy metabolism disorders, epigenetic regulation, and gut microbiota dysbiosis. This review systematically summarizes recent key advances in elucidating heart failure pathogenesis and iterative updates to treatment strategies, drawing on fundamental and translational research in this field.
SN  - 1530-6550
SN  - 2153-8174
ER  -