Effects of Crude Polysaccharides from Lentinula edodes Obtained by Ultrasound-Assisted Water Extraction on Metabolic and Hepatic Parameters in Obese Rats.
- 1Division of Food Science and Technology, Faculty of Agro-Industry, Chiang Mai University, Chiang Mai 50100, Thailand.
Abstract
A high-fat diet is associated with metabolic disorder, including obesity, insulin resistance, dyslipidemia, and hypertension. Polysaccharides derived from mushrooms have attracted interest for their potential metabolic and anti-inflammatory effects. Nevertheless, the impact of crude polysaccharides derived from the Lentinula edodes (Berk.) Pegler (PSC) on metabolic conditions linked to high-fat diets remains insufficiently studied. This study aimed to evaluate the bioactivity of PSC obtained using ultrasound-water extraction (UW) on metabolic parameters, hepatic function, and inflammation in rats fed a high-fat diet (HFD). Male Wistar rats (5 weeks old, 180-200 g; n = 6 per group) were assigned to normal-diet (ND) or high-fat-diet (HFD) groups, with or without PSC administration. PSC was administered by oral gavage at 400 mg/kg body weight/day for 4 weeks. Compared with the HFD group at week 20, the HFD+PSC group showed 30.44% lower body-weight gain, while LDL-C, AST, ALT, and IL-6 levels were 42.31%, 35.77%, 55.15%, and 41.78% lower. Histopathological examination showed reduced hepatic steatosis and inflammatory alterations following PSC extract administration, with the NAS decreasing from 5.60 ± 0.51 in the HFD group to 2.00 ± 0.32 in the PSC extract administration. The findings indicate that a PSC extract decreased various metabolic, hepatic, and inflammatory changes correlated with HFD. This study supports the potential of PSC extract as a mushrooms-derived functional ingredient to improve metabolic function.
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BibTeX
@article{phosarith2026effects,
title = {{Effects of Crude Polysaccharides from Lentinula edodes Obtained by Ultrasound-Assisted Water Extraction on Metabolic and Hepatic Parameters in Obese Rats.}},
author = {Nannapat Phosarith and Thanyaporn Siriwoharn and Wachira Jirarattanarangsri},
journal = {International journal of molecular sciences},
year = {2026},
month = sep,
doi = {10.3390/ijms27198631},
url = {https://europepmc.org/article/MED/42883879},
note = {CC BY},
}
RIS
TY - JOUR
TI - Effects of Crude Polysaccharides from Lentinula edodes Obtained by Ultrasound-Assisted Water Extraction on Metabolic and Hepatic Parameters in Obese Rats.
AU - Nannapat Phosarith
AU - Thanyaporn Siriwoharn
AU - Wachira Jirarattanarangsri
PY - 2026
DA - 2026/09/26
JO - International journal of molecular sciences
DO - 10.3390/ijms27198631
UR - https://europepmc.org/article/MED/42883879
AB - A high-fat diet is associated with metabolic disorder, including obesity, insulin resistance, dyslipidemia, and hypertension. Polysaccharides derived from mushrooms have attracted interest for their potential metabolic and anti-inflammatory effects. Nevertheless, the impact of crude polysaccharides derived from the Lentinula edodes (Berk.) Pegler (PSC) on metabolic conditions linked to high-fat diets remains insufficiently studied. This study aimed to evaluate the bioactivity of PSC obtained using ultrasound-water extraction (UW) on metabolic parameters, hepatic function, and inflammation in rats fed a high-fat diet (HFD). Male Wistar rats (5 weeks old, 180-200 g; n = 6 per group) were assigned to normal-diet (ND) or high-fat-diet (HFD) groups, with or without PSC administration. PSC was administered by oral gavage at 400 mg/kg body weight/day for 4 weeks. Compared with the HFD group at week 20, the HFD+PSC group showed 30.44% lower body-weight gain, while LDL-C, AST, ALT, and IL-6 levels were 42.31%, 35.77%, 55.15%, and 41.78% lower. Histopathological examination showed reduced hepatic steatosis and inflammatory alterations following PSC extract administration, with the NAS decreasing from 5.60 ± 0.51 in the HFD group to 2.00 ± 0.32 in the PSC extract administration. The findings indicate that a PSC extract decreased various metabolic, hepatic, and inflammatory changes correlated with HFD. This study supports the potential of PSC extract as a mushrooms-derived functional ingredient to improve metabolic function.
SN - 1422-0067
ER -