LncRNA A1BGAS1 Serves as a Tumor Suppressor in Non-Small Cell Lung Cancer by Modulating the Expression of miR-3942-5P.
- 1Department of Thoracic Surgery, Linyi People's Hospital, Linyi, China.
- 2Internal Medicine Department, Ward 1, Linyi Cancer Hospital, Linyi, China.
- 3Department of Surgery, Yinan County ShuangHou Town Health Center, Linyi, China.
Abstract
Non-small cell lung cancer (NSCLC), the leading contributor to global cancer mortality, is associated with a notably unfavorable prognosis. This study aims to explore the regulatory interaction between A1BG-AS1 and miR-3942-5p and its molecular mechanisms. The level of A1BG-AS1 and miR-3942-5p in both tumor tissues and cell lines (BEAS-2B, A549, H226) were measured using qPCR. Functional effects of A1BG-AS1 overexpression in NSCLC cells were evaluated through CCK-8, flow cytometry, and Transwell assays. The interaction between A1BG-AS1 and miR-3942-5p was validated through dual-luciferase reporter assays and rescue studies. A1BG-AS1 expression was markedly reduced in both NSCLC tissues and cell lines. A1BG-AS1 expression was significantly associated with various clinical parameters. Overexpression of A1BG-AS1 suppressed NSCLC cell function. Mechanistically, A1BG-AS1 interacted with and negatively regulated miR-3942-5p, and the antitumor effects of A1BG-AS1 overexpression were reversed by miR-3942-5p mimics.A1BG-AS1 inhibits NSCLC tumor progression by targeting miR-3942-5p.
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BibTeX
@article{du2026lncrna,
title = {{LncRNA A1BGAS1 Serves as a Tumor Suppressor in Non-Small Cell Lung Cancer by Modulating the Expression of miR-3942-5P.}},
author = {Jiahui Du and Zhenhua Li and Chunqiang Wang and Xuexi Zhang},
journal = {Journal of biochemical and molecular toxicology},
year = {2026},
month = oct,
doi = {10.1002/jbt.71151},
url = {https://europepmc.org/article/MED/42952240},
note = {CC BY-NC},
}
RIS
TY - JOUR
TI - LncRNA A1BGAS1 Serves as a Tumor Suppressor in Non-Small Cell Lung Cancer by Modulating the Expression of miR-3942-5P.
AU - Jiahui Du
AU - Zhenhua Li
AU - Chunqiang Wang
AU - Xuexi Zhang
PY - 2026
DA - 2026/10/28
JO - Journal of biochemical and molecular toxicology
DO - 10.1002/jbt.71151
UR - https://europepmc.org/article/MED/42952240
AB - Non-small cell lung cancer (NSCLC), the leading contributor to global cancer mortality, is associated with a notably unfavorable prognosis. This study aims to explore the regulatory interaction between A1BG-AS1 and miR-3942-5p and its molecular mechanisms. The level of A1BG-AS1 and miR-3942-5p in both tumor tissues and cell lines (BEAS-2B, A549, H226) were measured using qPCR. Functional effects of A1BG-AS1 overexpression in NSCLC cells were evaluated through CCK-8, flow cytometry, and Transwell assays. The interaction between A1BG-AS1 and miR-3942-5p was validated through dual-luciferase reporter assays and rescue studies. A1BG-AS1 expression was markedly reduced in both NSCLC tissues and cell lines. A1BG-AS1 expression was significantly associated with various clinical parameters. Overexpression of A1BG-AS1 suppressed NSCLC cell function. Mechanistically, A1BG-AS1 interacted with and negatively regulated miR-3942-5p, and the antitumor effects of A1BG-AS1 overexpression were reversed by miR-3942-5p mimics.A1BG-AS1 inhibits NSCLC tumor progression by targeting miR-3942-5p.
SN - 1095-6670
SN - 1099-0461
ER -