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Peer-reviewedCC BY-NC-NDInternal Medicine

Coexistent IgG4-Related Sclerosing Cholecystitis and Xanthogranulomatous Cholecystitis in the Gallbladder: A Case Report

Abstract

A man in his 70s had a history of immunoglobulin G4 (IgG4)-related lung disease. Abdominal ultrasonography revealed smooth wall thickening with a preserved layered structure in the gallbladder neck. The fundus showed irregular wall thickening and layered structure loss. These findings suggest the existence of two pathological entities within the gallbladder. Malignancy could not be ruled out. A cholecystocolonic fistula developed, and radical cholecystectomy and partial transverse colon resection were performed. A histopathological examination revealed IgG4-related sclerosing cholecystitis (IgG4-CC) of the neck and body and xanthogranulomatous cholecystitis (XGC) of the fundus. The fistula originated from the XGC lesion.

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BibTeX
@article{okuyama2026coexistent,
  title = {{Coexistent IgG4-Related Sclerosing Cholecystitis and Xanthogranulomatous Cholecystitis in the Gallbladder: A Case Report}},
  author = {Takaki Okuyama and Kazuyuki Matsumoto and Takayoshi Miyake and Susumu Shinoura and Tsuyoshi Okada and Hiromasa Takeda and Kosaku Morimoto and Shogo Kimura and Kensuke Takei and Ryuta Takenaka},
  journal = {Internal Medicine},
  year = {2026},
  month = aug,
  doi = {10.2169/internalmedicine.7755-26},
  url = {https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7755-26/_article},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Coexistent IgG4-Related Sclerosing Cholecystitis and Xanthogranulomatous Cholecystitis in the Gallbladder: A Case Report
AU  - Takaki Okuyama
AU  - Kazuyuki Matsumoto
AU  - Takayoshi Miyake
AU  - Susumu Shinoura
AU  - Tsuyoshi Okada
AU  - Hiromasa Takeda
AU  - Kosaku Morimoto
AU  - Shogo Kimura
AU  - Kensuke Takei
AU  - Ryuta Takenaka
PY  - 2026
DA  - 2026/08/25
JO  - Internal Medicine
DO  - 10.2169/internalmedicine.7755-26
UR  - https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7755-26/_article
AB  - A man in his 70s had a history of immunoglobulin G4 (IgG4)-related lung disease. Abdominal ultrasonography revealed smooth wall thickening with a preserved layered structure in the gallbladder neck. The fundus showed irregular wall thickening and layered structure loss. These findings suggest the existence of two pathological entities within the gallbladder. Malignancy could not be ruled out. A cholecystocolonic fistula developed, and radical cholecystectomy and partial transverse colon resection were performed. A histopathological examination revealed IgG4-related sclerosing cholecystitis (IgG4-CC) of the neck and body and xanthogranulomatous cholecystitis (XGC) of the fundus. The fistula originated from the XGC lesion.
SN  - 1349-7235
SN  - 0918-2918
ER  -