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Peer-reviewedCC BY-NCOman Medical Journal

An Extremely High Preoperative CA19-9 Cannot Exclude the Diagnosis of Xanthogranulomatous Cholecystitis: A Case Report and Literature Review

  • Mahmood Masud Al Awfi1
  • Salah Al Jabri2
  • Yahya Al Azri2
  • Zakiya Al Ajmi3
  1. 1General Surgery Residency Training Program, Oman Medical Specialty Board, Muscat, Oman
  2. 2General Surgery Department, Royal Hospital, Muscat, Oman
  3. 3Pathology Department, Royal Hospital, Muscat, Oman
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Abstract

Xanthogranulomatous cholecystitis is a rare idiopathic benign chronic inflammatory condition with a locally aggressive spread. Its clinical and radiological manifestation are variable and unpredictable. While it shares similarities with gallbladder cancer, Xanthogranulomatous cholecystitis does not necessitate aggressive surgical treatment. However, the considerable challenge to reach a preoperative diagnosis underscores the need for an aggressive surgical approach. Adding to this challenge, an extremely elevated CA19-9 is no longer a distinguishing factor.

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Cite

BibTeXRIS
BibTeX
@article{awfi2026extremely,
  title = {{An Extremely High Preoperative CA19-9 Cannot Exclude the Diagnosis of Xanthogranulomatous Cholecystitis: A Case Report and Literature Review}},
  author = {Mahmood Masud Al Awfi and Salah Al Jabri and Yahya Al Azri and Zakiya Al Ajmi},
  journal = {Oman Medical Journal},
  year = {2026},
  month = jul,
  doi = {10.5001/omj.2026.08},
  url = {https://doi.org/10.5001/omj.2026.08},
  note = {CC BY-NC},
}
RIS
TY  - JOUR
TI  - An Extremely High Preoperative CA19-9 Cannot Exclude the Diagnosis of Xanthogranulomatous Cholecystitis: A Case Report and Literature Review
AU  - Mahmood Masud Al Awfi
AU  - Salah Al Jabri
AU  - Yahya Al Azri
AU  - Zakiya Al Ajmi
PY  - 2026
DA  - 2026/07/31
JO  - Oman Medical Journal
DO  - 10.5001/omj.2026.08
UR  - https://doi.org/10.5001/omj.2026.08
AB  - Xanthogranulomatous cholecystitis is a rare idiopathic benign chronic inflammatory condition with a locally aggressive spread. Its clinical and radiological manifestation are variable and unpredictable. While it shares similarities with gallbladder cancer, Xanthogranulomatous cholecystitis does not necessitate aggressive surgical treatment. However, the considerable challenge to reach a preoperative diagnosis underscores the need for an aggressive surgical approach. Adding to this challenge, an extremely elevated CA19-9 is no longer a distinguishing factor.
SN  - 1999-768X
SN  - 2070-5204
ER  -