Amyloidosis and risk of psychiatric disorders-insights from a real-world nationwide registry.
- 1School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan; Division of Cardiovascular Medicine, Department of Medicine, China Medical University Hospital, Taichung, Taiwan. Electronic address: [email protected].
- 2Center for Drug Research and Development, Chang Gung University of Science and Technology, Taoyuan, Taiwan.
- 3Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan.
Abstract
Objective
This is a National Health Insurance (NHI) database research investigating the association between amyloidosis and psychiatric disorders risk.Methods
The amyloidosis cohort was identified from insured individuals with amyloidosis, who were newly diagnosed from 2009 to 2019. Both cohorts were followed up and the subsequent psychiatric disorder was the major outcome event for the research. The multivariable model were used to examine the effect of amyloidosis and risk factor on the risk of developing psychiatric disorder.Results
The psychiatric disorder incidence was higher in the amyloidosis than in the comparison cohort (11.3 vs. 10.3 per 1000 person-years, crude HR = 1.10, 95% CI 1.02-1.19), with adjusted HR (aHR) of 1.26 (95% CI 1.16-1.36). After controlling for the confounders, amyloidosis cohort had a 1.38- fold higher risk of senile and pre-senile organic psychotic conditions (95% CI 1.22‒1.57), 1.26-fold higher risk of bipolar affective disorder (95% CI 1.10‒1.45), and 1.16-fold higher risk of other organic psychotic conditions than comparison cohort (95% CI 1.01-1.32).Conclusions
The authors found that compared to a matched amyloidosis naïve cohort, psychiatric disorders risk was significantly higher in patients with amyloidosis. Among different psychiatric disorders, risks of senile and pre-senile organic psychotic conditions, bipolar affective disorder and other organic psychotic conditions were higher among people with amyloidosis.
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BibTeX
@article{hu2026amyloidosis,
title = {{Amyloidosis and risk of psychiatric disorders-insights from a real-world nationwide registry.}},
author = {Wei-Syun Hu and Po-Hsiang Liao and Cheng-Li Lin and Chih-Yang Huang},
journal = {Clinics (Sao Paulo, Brazil)},
year = {2026},
month = oct,
doi = {10.1016/j.clinsp.2026.101208},
url = {https://europepmc.org/article/MED/42887292},
note = {CC BY},
}
RIS
TY - JOUR
TI - Amyloidosis and risk of psychiatric disorders-insights from a real-world nationwide registry.
AU - Wei-Syun Hu
AU - Po-Hsiang Liao
AU - Cheng-Li Lin
AU - Chih-Yang Huang
PY - 2026
DA - 2026/10/16
JO - Clinics (Sao Paulo, Brazil)
DO - 10.1016/j.clinsp.2026.101208
UR - https://europepmc.org/article/MED/42887292
AB - Objective This is a National Health Insurance (NHI) database research investigating the association between amyloidosis and psychiatric disorders risk.Methods The amyloidosis cohort was identified from insured individuals with amyloidosis, who were newly diagnosed from 2009 to 2019. Both cohorts were followed up and the subsequent psychiatric disorder was the major outcome event for the research. The multivariable model were used to examine the effect of amyloidosis and risk factor on the risk of developing psychiatric disorder.Results The psychiatric disorder incidence was higher in the amyloidosis than in the comparison cohort (11.3 vs. 10.3 per 1000 person-years, crude HR = 1.10, 95% CI 1.02-1.19), with adjusted HR (aHR) of 1.26 (95% CI 1.16-1.36). After controlling for the confounders, amyloidosis cohort had a 1.38- fold higher risk of senile and pre-senile organic psychotic conditions (95% CI 1.22‒1.57), 1.26-fold higher risk of bipolar affective disorder (95% CI 1.10‒1.45), and 1.16-fold higher risk of other organic psychotic conditions than comparison cohort (95% CI 1.01-1.32).Conclusions The authors found that compared to a matched amyloidosis naïve cohort, psychiatric disorders risk was significantly higher in patients with amyloidosis. Among different psychiatric disorders, risks of senile and pre-senile organic psychotic conditions, bipolar affective disorder and other organic psychotic conditions were higher among people with amyloidosis.
SN - 1807-5932
SN - 1980-5322
ER -