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PreprintCC BYChemRxiv

Coupling Insoluble Pteroic Acid Using Quaternary Ammonium Salts: Synthesis of a Peptide Bearing a Folic Acid Moiety

  • Yuya Asahina1
  1. 1NIPPON SHOKUBAI CO., LTD, Nishi Otabi-cho, Suita, Osaka, 564-0034
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Abstract

Herein, I report a unique coupling method for insoluble pteroic acid. Tetraalkylammonium hydroxide effectively enabled solubilization, efficient coupling with an amine, and an easy workup process to produce folate-conjugated peptides. The generality and versatility were confirmed through coupling studies of several amino acids, demonstrating its applicability to the synthesis of various folate and pteroate conjugates.

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Cite

BibTeXRIS
BibTeX
@misc{asahina2026coupling,
  title = {{Coupling Insoluble Pteroic Acid Using Quaternary Ammonium Salts: Synthesis of a Peptide Bearing a Folic Acid Moiety}},
  author = {Yuya Asahina},
  howpublished = {ChemRxiv},
  year = {2026},
  month = sep,
  doi = {10.26434/chemrxiv.15008525/v1},
  url = {https://chemrxiv.org/doi/full/10.26434/chemrxiv.15008525/v1},
  note = {CC BY},
}
RIS
TY  - UNPB
TI  - Coupling Insoluble Pteroic Acid Using Quaternary Ammonium Salts: Synthesis of a Peptide Bearing a Folic Acid Moiety
AU  - Yuya Asahina
PY  - 2026
DA  - 2026/09/08
PB  - ChemRxiv
DO  - 10.26434/chemrxiv.15008525/v1
UR  - https://chemrxiv.org/doi/full/10.26434/chemrxiv.15008525/v1
AB  - Herein, I report a unique coupling method for insoluble pteroic acid. Tetraalkylammonium hydroxide effectively enabled solubilization, efficient coupling with an amine, and an easy workup process to produce folate-conjugated peptides. The generality and versatility were confirmed through coupling studies of several amino acids, demonstrating its applicability to the synthesis of various folate and pteroate conjugates.
ER  -