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Peer-reviewedCC BYJournal of Functional Foods

Water-soluble tomato concentrate as a natural modulator of angiogenesis: Integrated

  • Keerthi Nethaji1
  • Amit Dey1
  • Surajit Pathak1
  • Asim K. Duttaroy2
  • Antara Banerjee3
  1. 1Medical Biotechnology Lab, Faculty of Allied and Healthcare Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam 603103, India
  2. 2Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Norway; Corresponding authors.
  3. 3Medical Biotechnology Lab, Faculty of Allied and Healthcare Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam 603103, India; Corresponding authors.
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Abstract

Introduction: Angiogenesis is essential for vascular repair and the restoration of blood flow after ischemic injury. The water-soluble tomato concentrate has established cardioprotective and antiplatelet properties, but has not been extensively investigated for its potential to promote angiogenesis. Methods: Human umbilical vein endothelial cells (HUVECs) were treated with various concentrations of water-soluble tomato concentrate. Endothelial cell viability, apoptosis, intracellular reactive oxygen species, tube formation, and angiogenesis-related gene expression were studied. An in ovo chick chorioallantoic membrane assay was performed to assess vascular development and maturation. Results: Water-soluble tomato concentrate increased cell viability, modulated intracellular ROS levels, promoted capillary-like tube formation, and upregulated expression of VEGF-A, PECAM-1 , and ENDOGLIN . CAM assay showed increased vascular density and supported vascular maturation. Conclusion: Water-soluble tomato concentrate may promote vascular regeneration and support vascular health, exhibiting pro-angiogenic properties in vitro and in ovo . Further preclinical and clinical studies are needed to determine whether the water-soluble tomato concentrate may provide translational benefits for vascular regeneration and endothelial function in humans.

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Cite

BibTeXRIS
BibTeX
@article{nethaji2026watersoluble,
  title = {{Water-soluble tomato concentrate as a natural modulator of angiogenesis: Integrated}},
  author = {Keerthi Nethaji and Amit Dey and Surajit Pathak and Asim K. Duttaroy and Antara Banerjee},
  journal = {Journal of Functional Foods},
  year = {2026},
  month = oct,
  doi = {10.1016/j.jff.2026.107550},
  url = {https://doi.org/10.1016/j.jff.2026.107550},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Water-soluble tomato concentrate as a natural modulator of angiogenesis: Integrated
AU  - Keerthi Nethaji
AU  - Amit Dey
AU  - Surajit Pathak
AU  - Asim K. Duttaroy
AU  - Antara Banerjee
PY  - 2026
DA  - 2026/10/30
JO  - Journal of Functional Foods
DO  - 10.1016/j.jff.2026.107550
UR  - https://doi.org/10.1016/j.jff.2026.107550
AB  - Introduction: Angiogenesis is essential for vascular repair and the restoration of blood flow after ischemic injury. The water-soluble tomato concentrate has established cardioprotective and antiplatelet properties, but has not been extensively investigated for its potential to promote angiogenesis. Methods: Human umbilical vein endothelial cells (HUVECs) were treated with various concentrations of water-soluble tomato concentrate. Endothelial cell viability, apoptosis, intracellular reactive oxygen species, tube formation, and angiogenesis-related gene expression were studied. An in ovo chick chorioallantoic membrane assay was performed to assess vascular development and maturation. Results: Water-soluble tomato concentrate increased cell viability, modulated intracellular ROS levels, promoted capillary-like tube formation, and upregulated expression of VEGF-A, PECAM-1 , and ENDOGLIN . CAM assay showed increased vascular density and supported vascular maturation. Conclusion: Water-soluble tomato concentrate may promote vascular regeneration and support vascular health, exhibiting pro-angiogenic properties in vitro and in ovo . Further preclinical and clinical studies are needed to determine whether the water-soluble tomato concentrate may provide translational benefits for vascular regeneration and endothelial function in humans.
SN  - 1756-4646
SN  - 2214-9414
ER  -