Mitophagy coordinates organelle crosstalk in health and diseases.
10 affiliations
- 1Medical Innovation Research Department of the Chinese PLA General Hospital, Beijing, China.
- 2School of Medicine, Nankai University, Tianjin, China.
- 3School of Traditional Chinese Medicine, Nanjing University of Traditional Chinese Medicine, Nanjing, China.
- 4Department of Critical Care Medicine, the First Medical Center of the Chinese PLA General Hospital, Beijing, China.
- 5Department of Critical Care Medicine, the Fifth Medical Center of the Chinese PLA General Hospital, Beijing, China.
- 6Center for DAMP Biology, Department of Surgery, UT Southwestern Medical Center, Dallas, TX, USA. [email protected].
- 7Medical Innovation Research Department of the Chinese PLA General Hospital, Beijing, China. [email protected].
- 8National Clinical Research Center for Geriatric Diseases, the Chinese PLA General Hospital, Beijing, China. [email protected].
- 9Medical Innovation Research Department of the Chinese PLA General Hospital, Beijing, China. [email protected].
- 10Department of General Surgery, the First Medical Center of the Chinese PLA General Hospital, Beijing, China. [email protected].
Abstract
Eukaryotic cells contain various membrane- and non-membrane-bound organelles, whose spatial and functional organization underpins intracellular homeostasis. Organelle coordination is governed by complex signaling and metabolic networks, often facilitated by direct physical contacts and molecular exchange. Mitochondria, as central hubs of bioenergetic and metabolic activity, are essential to functional coordination among cellular organelles. They engage in diverse cellular processes, encompassing ATP production, biosynthesis of key metabolites, calcium ion buffering, redox balance, and cellular turnover. To preserve their integrity and functionality, dysfunctional mitochondria undergo selective elimination via mitophagy, a specialized form of macroautophagy. Mitophagy plays dual roles in maintaining mitochondrial fidelity and actively shapes interorganelle communication. Through bidirectional signaling, mitophagy influences the activity of multiple organelles, including the endoplasmic reticulum, nucleus, lysosomes, peroxisomes, and lipid droplets. This interorganelle crosstalk is essential for adapting to metabolic stress, maintaining redox balance, and coordinating cell fate decisions. In this review, we explore the intricate signaling networks connecting mitophagy with various organelles and discuss how these interactions influence organ function and overall cellular health. We also highlight emerging small-molecule modulators of mitophagy, providing insight into potential therapeutic strategies aimed at restoring or enhancing organelle communication in pathological conditions.
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BibTeX
@article{wu2026mitophagy,
title = {{Mitophagy coordinates organelle crosstalk in health and diseases.}},
author = {Mengyao Wu and Pengyi He and Yajun Lian and Tuo Zhang and Yiqi Wu and Lu Wang and Daolin Tang and Yongming Yao and Renqi Yao},
journal = {Signal transduction and targeted therapy},
year = {2026},
month = oct,
doi = {10.1038/s41392-026-02812-3},
url = {https://europepmc.org/article/MED/42897134},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Mitophagy coordinates organelle crosstalk in health and diseases.
AU - Mengyao Wu
AU - Pengyi He
AU - Yajun Lian
AU - Tuo Zhang
AU - Yiqi Wu
AU - Lu Wang
AU - Daolin Tang
AU - Yongming Yao
AU - Renqi Yao
PY - 2026
DA - 2026/10/20
JO - Signal transduction and targeted therapy
DO - 10.1038/s41392-026-02812-3
UR - https://europepmc.org/article/MED/42897134
AB - Eukaryotic cells contain various membrane- and non-membrane-bound organelles, whose spatial and functional organization underpins intracellular homeostasis. Organelle coordination is governed by complex signaling and metabolic networks, often facilitated by direct physical contacts and molecular exchange. Mitochondria, as central hubs of bioenergetic and metabolic activity, are essential to functional coordination among cellular organelles. They engage in diverse cellular processes, encompassing ATP production, biosynthesis of key metabolites, calcium ion buffering, redox balance, and cellular turnover. To preserve their integrity and functionality, dysfunctional mitochondria undergo selective elimination via mitophagy, a specialized form of macroautophagy. Mitophagy plays dual roles in maintaining mitochondrial fidelity and actively shapes interorganelle communication. Through bidirectional signaling, mitophagy influences the activity of multiple organelles, including the endoplasmic reticulum, nucleus, lysosomes, peroxisomes, and lipid droplets. This interorganelle crosstalk is essential for adapting to metabolic stress, maintaining redox balance, and coordinating cell fate decisions. In this review, we explore the intricate signaling networks connecting mitophagy with various organelles and discuss how these interactions influence organ function and overall cellular health. We also highlight emerging small-molecule modulators of mitophagy, providing insight into potential therapeutic strategies aimed at restoring or enhancing organelle communication in pathological conditions.
SN - 2095-9907
SN - 2059-3635
ER -